| Cellular and Molecular Neurosciences Section |
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Mark P. Mattson, Ph.D., Chief
Senior Investigator |
| Overview: The Cellular and Molecular Neurosciences Section employs a multifaceted array of experimental models of aging and age-related neurodegenerative disorders in order to establish the molecular and biochemical changes that occur during aging and in disorders such as Alzheimer's, Parkinson's and Huntington's diseases and stroke. Data obtained in these experimental models are integrated with data obtained in studies of both normal elderly humans and patients with neurodegenerative disorders to arrive at conclusions as to why neuronal dysfunction and degeneration occur in the disorders. In addition to identifying the molecular and cellular alterations that lead to neuronal degeneration in age-related neurological disorders, investigators are elucidating the cellular signaling mechanisms that allow successful brain aging. |
| In general, the projects underway fall into the following areas: |
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