This area would involve sequencing genes implicated in common disorders in large, well-phenotyped cohorts. Potential examples include genes that contribute to blood pressure, type 2 diabetes, epilepsy, and neurodegeneration. The genomic locus encompassing each gene would be completely sequenced in every member of one or more large cohorts of individuals (i.e. thousands), to obtain adequate power, sampled from the full trait distribution, in whom relevant physiological parameters have been accurately measured, perhaps augmented by a reference resource such as HapMap.
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