Study Provides Clues about How Cancer Cells Develop Resistance to Chemotherapy Drug
(Posted: 09/14/2008) - Researchers have shown that increased expression of a gene called SIRT1 in cancer cells plays a significant role in the development of resistance to the chemotherapy drug cisplatin.
The Cancer Genome Atlas Reports First Results of Comprehensive Study of Brain Tumors: Large-Scale Effort Identifies New Genetic Mutations, Core Pathways
(Posted: 09/04/2008) - The Cancer Genome Atlas (TCGA) Research Network today reported the first results of its large-scale, comprehensive study of the most common form of brain cancer, glioblastoma (GBM). In a paper published Sept. 4, 2008, in the advance online edition of the journal Nature, the TCGA team describes the discovery of new genetic mutations and other types of DNA alterations with potential implications for the diagnosis and treatment of GBM.
Alternative Vaccine Strategy Shows Promise in Prostate Cancer Patients
(Posted: 08/15/2008) - New research indicates that giving patients a continuous low dose of an immune system booster, a method known as metronomic dosing, as part of a therapeutic prostate cancer vaccine strategy is safe and produces similar immune responses and fewer side effects than the more common dosing method, which is not well tolerated by many patients. This study, led by researchers at that National Cancer Institute (NCI), part of the National Institutes of Health, was published in the August 15, 2008, issue of Clinical Cancer Research.
New Research Results Explain How Dormant Tumor Cells Become Active in Later Years
(Posted: 08/01/2008) - Scientists using a three-dimensional cell culture system have identified a mechanism by which dormant, metastatic tumor cells can begin growing again after long periods of inactivity. The new findings indicate that the switch from dormancy to proliferative, metastatic growth may be regulated, in part, through signaling from the surrounding microenvironment, which leads to changes in the skeletal architecture of dormant tumor cells. Targeting this mechanism may also provide strategies for inhibiting the switch from dormancy to proliferation.
Imaging Techniques Yield New Information on How HIV Infects Cells and Provides Clues to Vaccine Design
(Posted: 07/30/2008) - The use of advanced imaging techniques has allowed researchers to visualize how a key part of the human immunodeficiency virus (HIV) changes shape after binding to immune system cells or to infection-fighting antibodies. Although scientists had been able to visualize individual components of this part of the virus, called the HIV spike, the new research characterizes, for the first time, the structure of the intact spike on virus particles, which is a crucial piece of knowledge that may aid the design of new vaccines or drugs to fight HIV infection.
Laboratory and Mouse Studies Show Targeted Drug Blocks the Growth of Breast Cancer Cells that Spread to the Brain
(Posted: 07/29/2008) - Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific proteins on the surface of breast cancer cells can inhibit the growth of breast cancer cells that migrate to the brain.
Researchers Develop a Method to Evaluate Variations Identified in Breast Cancer Susceptibility Genes
(Posted: 07/06/2008) - Using mouse embryonic stem cells, researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have developed a new method to evaluate which mutations, or changes, in a gene known to increase breast cancer susceptibility, may lead to cancer.
How to Move Cancer Research Forward: Public/Private Partnerships - a NCI Science Writer's Seminar
(Posted: 07/01/2008) - Please join us for a science writers' seminar to discuss public/private partnerships in cancer research. Among the topics discussed will be working with industry to develop new drugs; cancer vaccine development and business barriers; working with small businesses to develop new technologies to catch cancer in its earliest stages; and intellectual property rights and technology transfer issues related to new genetic tests. The seminar will be in a classroom setting with ample time for Q&A and interaction during the talks.
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