In the fall of 2000, a young healthy male died following snorting an excessive amount of 2C-T-7. Since this initial 2C-T-7-related death, two additional deaths reported in April 2001 have been linked to 2C-T-7. These two deaths resulted from the co-abuse of 2C-T-7 with MDMA.

2C-T-7 is not approved for marketing by the Food and Drug Administration and is not sold legally in the United States.

2,5-Dimethoxy-4- (n)-propylthiophenethylamine (2C-T-7), is a phenethylamine hallucinogen that is structurally related to the schedule I phenethylamine hallucinogens, 4-bromo-2, 5-dimethoxyphenethylamine (2C-B, Nexus) and mescaline. Based on structural similarly to these compounds, the pharmacological profile of 2C-T-7 is expected to be qualitatively similar to these hallucinogens.

Drug discrimination studies in animals indicate that 2C-T-7 produces subjective effects similar to those of several schedule I hallucinogens. Subjective effects of 2C-T-7 were shown to be similar to 2,5-dimethoxy-4-methyl-amphetamine (DOM). In rats trained to discriminate DOM, 2C-T-7 fully substituted for DOM and was slightly less potent than 2C-B in eliciting DOM-like effects. 2C-T-7 was also shown to share some commonality with LSD; it partially substituted for LSD up to doses that severely disrupted performance in rats trained to discriminate LSD. 2C-T-7 can also function as a discriminative stimulus in rats. Rats readily learned to discriminate 2C-T-7 from saline. When either 2C-B or LSD was substituted for 2C-T-7, each elicited 2C-T-7-like discriminative stimulus effects.

The subjective effects of 2C-T-7, like those of 2C-B and DOM, appear to be mediated through central serotonin receptors. 2C-T-7 selectively binds to the 5-HT receptor system.

According to one published case report, 2C-T-7 abuse has been associated with convulsions in humans.

emotionality, volatility, increased appreciation of music, and psychedelic ideation. The oral and intranasal doses recommended on this website are 10-50 mg and 5-10 mg, respectively. 2C-T-7’s onset and duration of actions are dependent upon the route of administration. Following oral administration, onset and duration of effects are 1 to 2.5 hours and 5 to 7 hours, respectively. After intranasal administration, the onset of action and duration of effects are 5 to 15 minutes and 2 to 4 hours, respectively.

Young adults are the main abusers of 2C-T-7.

According to National Forensic Laboratory Information System (NFLIS), since 2001, state and local forensic laboratories analyzed 35 items of 2C-T-7 from 6 different law enforcement cases. According to NFLIS, 2C-T-7 has been encountered in California, Florida, Minnesota, Texas and Wisconsin.

One exhibit analyzed by the Wisconsin State Crime Lab was shown be a mixture of 2C-T-7 and N,N-dipropyltryptamine (DPT). 2C-T-7 was being purchased over the Internet from a company located in Indiana. This site was traced to an individual who had been selling large quantities of this substance since January 2000. Sales through this Internet site were thought to be the major sources of 2C-T-7 in the United States. One clandestine laboratory was identified in Las Vegas, Nevada as the supplier of 2C-T-7 to the individual in Indiana. 2C-T-7 has been sold under the street names Blue Mystic, T7, Beautiful, Tweety-Bird Mescaline or Tripstay.

2C-T-7 was temporarily placed into schedule I (CI) of the Controlled Substances Act (CSA) on September 20, 2002 (67 FR 59163). On March 18, 2004, the DEA published a Final Rule in the Federal Register permanently placing 2C-T-7 in CI (69 FR 12794).