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Publications: A Guide to the Clinical Care of Women with HIV/AIDS, 2005 edition


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  Introduction
    Editor
    Forward
    Dedication
    Acknowledgements
    Contributing Authors
    Abbreviations

Introduction

Editor  TOP

JEAN R. ANDERSON, MD

Associate Professor
Departments of Gynecology, Obstetrics, and Medicine
The Johns Hopkins University School of Medicine
Departments of Population and Family Health Sciences
The Johns Hopkins University School of Public Health

Recommendations change rapidly in HIV care, so the care provider is cautioned that this edition is dated 2005. For the most current and continually updated HIV/AIDS treatment guidelines, contact AIDSinfo at:

http://www.aidsinfo.nih.gov

This Guide contains information relating to general principles of medical care which should not be construed as specific instructions for individual patients. Some of the information may cite the use of a particular drug in a dosage, for an indication, or in a manner other than recommended. Therefore, the manufacturer’s package inserts should be consulted for complete prescribing information.

DEPARTMENT OF HEALTH AND HUMAN SERVICES
HEALTH RESOURCES AND SERVICES ADMINISTRATION
HIV/AIDS BUREAU
PARKLAWN BUILDING, ROOM 7-13
5600 FISHERS LANE
ROCKVILLE MD 20857
http://www.hab.hrsa.gov
Publication date 2005


Forward  TOP

A Guide to the Clinical Care of Women with HIV is a comprehensive clinical manual that addresses the primary care needs unique to women with HIV infection. The target audience is clinicians who provide primary care to women as well as those seeking a more in-depth understanding of how to care for women with HIV/AIDS. This 2005 edition of the guide, first published in 2001, has been updated and chapters have been added on international issues and nutrition.

A manual devoted specifically to the care of women with HIV is important. Because women are often challenged by social isolation, poverty, discrimination and lack of access to quality health care, they tend to be diagnosed later and to have poorer health status than men. They must contend with vulnerability related to reproductive and gender issues and domestic violence. Finally, women living with HIV are usually relied upon to meet the care needs of children and other family members, many of whom are also HIV-positive.


Dedication  TOP

We want to acknowledge the women with HIV/AIDS who have been the inspiration for this Guide. Their strength is celebrated and their struggle is not forgotten. We offer this Guide as a tribute to them, and to the providers who have taken on this struggle and made it their own.


Acknowledgements  TOP

A number of people made this Guide possible. Joan Holloway provided the framework for the Guide’s inception and development. Magda Barini-García, MD, MPH was the Project Officer who shepherded and oversaw the project. Helen Schietinger, the project manager, coordinated the production process and brought it to fruition. Laura Spofford designed the cover. For the 2005 edition, Patrice Lincoln was the typographer and designer and Bill Todd was the copyeditor and indexer.

For the 2005 Edition, the chapters were reviewed by the following experts:

Dawn Averitt
Founder and CEO, The Well Project
Kirsten B. Balano, PharmD
University of California, San Francisco
John G. Bartlett, MD
The Johns Hopkins University School of Medicine
Gail V. Berkenblit, MD, PhD
The Johns Hopkins University School of Medicine
Jonathan Ellen, MD
The Johns Hopkins University School of Medicine
Thurma McCann Goldman, MD
HIV/AIDS Bureau, HRSA
Laura A. Guay MD
The Johns Hopkins University School of Medicine
Lisa Ruth Hirschhorn, MD
Harvard University Medical School
Gregory M. Lucas, MD, PhD
The Johns Hopkins University School of Medicine
Mary E. McCaul, PhD
The Johns Hopkins University School of Medicine
Howard L. Minkoff, MD
State University of New York at Stonybrook School of Medicine
Helen Miramontes, RN, MSN, FAAN
School of Nursing, University of California, San Francisco (Emeritus)
Ila Mulasi, MD
University of Maryland School of Medicine
Eula W. Pines, PhD, APRN, BC
University of the Incarnate Word
Timothy R. Sterling, MD
Vanderbilt University School of Medicine
Glenn J. Treisman, MD, PhD
The Johns Hopkins University School of Medicine
Ruth Ellen Tuomala, MD
Harvard University Medical School
Jonathan Zenilman, MD
The Johns Hopkins University School of Medicine

Contributing Authors  TOP

Silvia M. Abularach, MD, MPH
Assistant Professor
Department of Gynecology and Obstetrics
The Johns Hopkins University School of Medicine
Baltimore, MD, U.S.
Carla S. Alexander, MD
Assistant Professor of Medicine
University of Maryland School of Medicine
Baltimore, MD, U.S.
Jean R. Anderson, MD
Associate Professor
Departments of Gynecology, Obstetrics, and Medicine
The Johns Hopkins University School of Medicine
Departments of Population and Family Health Sciences
The Johns Hopkins University School of Public Health
Baltimore, MD, U.S.
Barbara Aranda-Naranjo, PhD, RN, FAAN
Scanlon Endowed Chair in Values Based Health Care
Nursing and Health Studies
Georgetown University
Washington, DC, U.S.
Jared M. Baeten, MD, PhD
Department of Medicine
Massachusetts General Hospital
Boston, MA, U.S.
Patricia Barditch-Crovo, MD
Assistant Professor
Division of Infectious Diseases
The Johns Hopkins University School of Medicine
Baltimore, MD, U.S.
Magda Barini-García, MD, MPH
Senior Medical Advisor
HRSA Center for Quality
HIV/AIDS Bureau, Health Resources and Services Administration
Rockville, MD, U.S.
Victoria A. Cargill, MD, MSCE
Director of Minority Research, Director of Clinical Studies
Office of AIDS Research
National Institutes of Health
Bethesda, MD, U.S.
Connie Celum, MD, MPH
Professor of Medicine and Adjunct Professor of Epidemiology
University of Washington
Seattle, WA, U.S.
Laura Cheever, MD, ScM
Deputy Associate Administrator
Chief Medical Officer
HIV/AIDS Bureau, Health Resources and Services Administration
Rockville, MD, U.S.
Rachel Davis, RN, ACRN
Field Nurse Case Manager
Concentra Integrated Services, Inc.
Pleasanton, TX, U.S.
Judith Y. Ellis, MS
Division of Training and Technical Assistance
HRSA Center for Quality
HIV/AIDS Bureau, Health Resources and Services Administration
Rockville, MD, U.S.
Judith Feinberg, MD
Professor of Medicine
University of Cincinnati College of Medicine
Cincinnati, OH, U.S.
Henry Francis, MD
Director, Center on AIDS and Other Medical Consequences of Drug Abuse (CAMCODA)
National Institute on Drug Abuse, National Institutes of Health
Bethesda, MD, U.S.
Donna Futterman, MD
Professor of Clinical Pediatrics, Albert Einstein College of Medicine
Director, Adolescent AIDS Program, Montefiore Medical Center
Bronx, NY, U.S.
Monica Gandhi, MD, MPH
Assistant ProfessorDivision of Infectious Diseases
University of California, San Francisco
San Francisco, CA, U.S.
Ruth M. Greenblatt, MD
Professor of Medicine, Epidemiology and Biostatistics
University of California at San Francisco
San Francisco, CA, U.S.
Nancy A. Hessol, MSPH
Assistant Professor Department of Medicine
University of California, San Francisco
San Francisco, CA, U.S.
Dorothy Kasonde, MBCHB, MMed
Antiretroviral Consultant
JHPIEGO/Zambia
Lusaka, Zambia
Joyce Seiko Kobayashi, MD
Associate Professor
University of Colorado Health Sciences Center
Denver, CO, U.S.
Rani Lewis, MD
Division Director for Maternal Fetal Medicine
Meharry School of Medicine
Nashville, TN, U.S.
Janine Maenza, MD
Clinical Assistant Professor
Division of Allergy and Infectious Diseases, Department of Medicine
University of Washington
Seattle, WA, U.S.
Paul Pham, PharmD
Research Associate
Division of Infectious Diseases
The Johns Hopkins University School of Medicine
Baltimore, MD, U.S.
Moses Pounds, PhD
Deputy Chief
Service Evaluation and Research Branch
Office of Science & Epidemiology
HIV/AIDS Bureau, Health Resources and Services Administration
Rockville, MD, U.S.
Helen Schietinger, MA, ACRN
HIV Policy Analyst
Washington, DC, U.S.
Suniti Solomon, MD
Founding Director
Y.R.Gaitonde (YRG) Centre for AIDS Research and Education
Chennai, India
Valdiléa Gonçalves Veloso Dos Santos, MD, MSc
Associate Researcher
Evandro Chagas Clinical Research Institute
Oswaldo Cruz Foundation
Rio Di Janiero, Brazil
Chia C. Wang, MD, MS
Assistant Professor Department of Medicine
Division of Infectious Diseases University of Washington
Seattle, WA, U.S.

Abbreviations  TOP

Nos A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Nos  SECTION TOP

3TC Lamivudine
5-FU 5-fluorouracil

A  SECTION TOP

A-aDO2 Alveolar to arterial oxygen difference
ABC Abacavir
ACOG American College of Obstetricians and Gynecologists
ADC AIDS dementia complex
ADR Adverse drug reaction
AFB Acid-fast bacilli
AFI Amniotic fluid index
AFP Alfa fetoprotein
AGC Atypical glandular cells
ALT Alanine aminotransferase
Anti-HBc Hepatitis B core antibody
Anti-HBs Hepatitis B surface antibody
AP Antepartum
APAP Acetaminophen
APV Amprenavir
ARV Antiretroviral
ASA Aspirin (acetylsalicylic acid)
ASC-H Anal squamous intraepithelial lesions—cannot exclude HSIL
ASCUS Anal squamous intraepithelial lesions—undetermined significance
ASIL Anal squamous intraepithelial lesions
ATV Atazanavir
AUC Area under the concentration-time curve
AZT Zidovudine

B  SECTION TOP

bDNA Branched DNA
bid 2 times daily
biw 2 times weekly
BMI Body mass index
BV Bacterial vaginosis
bx Biopsy

C  SECTION TOP

CASI Computer assisted self-interviewing
CBC Complete blood count
CBV Combivir
CDC Centers for Disease Control and Prevention
CEA Carcinoembryonic antigen
CES-D Center for Epidemiological Studies Depression scale
CI Confidence interval
CIN1, -2, -3 Cervical intraepithelial neoplasia, grade 1 (2, 3)
CLIA Clinical Laboratory Improvements Amendments
Cmax Peak serum concentration
Cmin Trough serum concentration
CMV Cytomegalovirus
CNS Central nervous system
CPK Creatinine phosphokinase
CrCl Creatinine clearance
CSF Cerebrospinal fluid
CST Contraction stress test
CT Computed tomography
CVD Cardiovascular disease
CXR Chest x-ray

D  SECTION TOP

d Day
d/c Discontinue
d4T Stavudine
ddC Zalcitibine
ddI Didanosine
DEXA Dual-energy X-ray absorptiometry
DFA Direct fluorescent antibody
DLV Delavirdine
DMPA Depo-medroxyprogesterone acetate
DOT Directly observed therapy
DRESS Drug rash, eosinophilia, systemic symptoms
DS Double strength
dT Diphtheria/tetanus toxoid
DVT Deep venous thrombosis

E  SECTION TOP

EBV Epstein-Barr virus
EC Enteric coated
EFV Efavirenz
ELISA Enzyme-linked immunosorbent assay
EM Electron microscopy
EMG Electromyelogram
ERCP Endoscopic retrograde cholangiopancreatography
ESR Erythrocyte sedimentation rate
ETOH Ethyl alcohol

F  SECTION TOP

FA Fluorescent antibody
FDA Food and Drug Administration
FSH Follicle stimulating hormone
FTA Fluorescent treponemal antibody
FTC Emtracitabine
FUO Fever of unknown origin

G  SECTION TOP

G6PD Glucose-6-phosphate dehydrogenase
GBS Group B Streptococci
GBV-C GB virus type C
GC Gonorrhea culture
G-CSF Granulocyte-colony stimulating factor
GI Gastrointestinal
GTT Glucose tolerance test

H  SECTION TOP

H&E Hematoxylin and eosin
HAART Highly active antiretroviral therapy
HAD HIV-associated dementia
HAV Hepatitis A virus
HBIG Hepatitis B immunoglobulin
HbsAg Hepatitis B surface antigen
HBV Hepatitis B virus
HCG Human chorionic gonadotropin
HCSUS HIV Cost and Services Utilization Study
HCV Hepatitis C virus
HDL High-density lipoprotein
HERS HIV Epidemiology Research Study
hgc Hard gel capsule
HLA Human leukocyte antigen
HPV Human papillomavirus
hr Hour
HRT Hormone replacement therapy
HSIL High-grade squamous intraepithelial lesion
HSV Herpes simplex virus
HTLV Human T-cell lymphotropic virus

I  SECTION TOP

IDSA Infectious Disease Society of America
IDU Injection drug use/user
IDV Indinavir
IgA Immunoglobulin A (E, G, M, etc.)
im Intramuscularly
INH Isoniazid
INR International normalization ratio
IP Intrapartum
IUD Intrauterine device
iv Intravenously
IVP Intravenous pyelogram

J  SECTION TOP

JC virus (Initials of index case of PML)

K  SECTION TOP

KOH Potassium hydroxide
KS Kaposi sarcoma

L  SECTION TOP

LAAM L-a-acetyl-methadol
LCR Ligase chain reaction
LDH Lactic dehydrogenase
LDL Low-density lipoprotein
LFT Liver function test
LIP Lymphoid interstitial pneumonia
LP Lumbar puncture
LPV Lopinavir
LTS Long-term survival

M  SECTION TOP

MAC Mycobacterium avium complex
MCMD Minor cognitive-motor disorder
MDD Major depressive disorder
MDMA Methylenedioxymethamphetamine (ecstasy)
MMR Measles, mumps and rubella
mo Month
MPA Medroxyprogesterone acetate
MRI Magnetic resonance imaging
MSM Men who have sex with men
MTCT Mother-to-child transmission
MTPA Methoxy (trifluoromethyl) phenylacetic acid

N  SECTION TOP

N/V/D Nausea/vomiting/diarrhea
N-9 Nonoxynol-9
NASBA Nucleic acid sequence-based amplification
NFV Nelfinavir
NIDU Non-injection drug use
NIH National Institutes of Health
NIMH National Institute of Mental Health
NNRTI Non-nucleoside reverse transcriptase inhibitor
NOS Not otherwise specified
NRTI Nucleoside reverse transcriptase inhibitor
NSAID Nonsteroidal anti-inflammatory drug
NST Non-stress test

O  SECTION TOP

O&P Ova and parasites
OC Oral contraceptive
OI Opportunistic infection
OR Odds ratio

P  SECTION TOP

PACTG Pediatric AIDS Clinical Trials Group
PACTS Perinatal AIDS Collaborative Transmission Study
PaO2 Partial pressure of oxygen
PCN Penicillin
PCP Pneumocystis jiroveci (formerly carinii) pneumonia
PCR Polymerase chain reaction
PEP Postexposure prophylaxis
PGL Persistent generalized lymphadenopathy
PI Protease inhibitor
PID Pelvic inflammatory disease
PK Pharmacokinetic
PLWHA People living with HIV/AIDS
PML Progressive multifocal leukoencephalopathy
PMTCT Prevention of mother-to-child transmission
po By mouth
PP Postpartum
PPD Purified protein derivative
PSN Predominantly sensory neuropathy
PTSD Post-traumatic stress disorder
PV Vaginally

Q  SECTION TOP

qd 1 time daily
qm 1 time monthly
qod Every other day
qw 1 time weekly

R  SECTION TOP

r/o Rule out
RIBA Recombinant immunoblot assay
RNA Ribonucleic acid
RPR Rapid plasma reagin
RT-PCR Reverse transcriptase polymerase chain reaction
RTV Ritonavir

S  SECTION TOP

sc Subcutaneously
sgc Soft gel capsule
SI Syncytium-inducing
SIL Squamous intraepithelial lesions
SIV Simian immunodeficiency virus
SMX Sulfamethoxazole
SOC States of Change behavior theory
SP Sulfadioxone pyrimethamine
sq Subcutaneous
SQV Saquinavir
SS Single strength
SSRI Selective serotonin reuptake inhibitor
STI Sexually transmitted infection
sx Symptom

T  SECTION TOP

TAM Thymidine-associated mutation
TB Tuberculosis
Td Tetanus/diphtheria
TDM Therapeutic drug monitoring
TE Toxoplasmic encephalitis
TIBC Total iron binding capacity
tid 3 times daily
tiw 3 times weekly
TMP Trimethoprim
TSH Thyroid-stimulating hormone
TSS Toxic shock syndrome
TST Tuberculin skin test

U  SECTION TOP

UNAIDS United Nations Program on AIDS
USPHS United States Public Health Service

V  SECTION TOP

VCT Voluntary counseling and testing
VDRL Venereal Disease Research Laboratory slide test
VZV Varicella zoster virus

W  SECTION TOP

WBC White blood cell
WHO World Health Organization
WIHS Women’s Interagency HIV Study
WITS Women and Infants Transmission Study

Y  SECTION TOP

yr Year
 


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