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Nat Genet. 2008 Sep;40(9):1042-4.
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
O'Donovan MC,
Craddock N,
Norton N,
Williams H,
Peirce T,
Moskvina V,
Nikolov I,
Hamshere M,
Carroll L,
Georgieva L,
Dwyer S,
Holmans P,
Marchini JL,
Spencer CC,
Howie B,
Leung HT,
Hartmann AM,
Möller HJ,
Morris DW,
Shi Y,
Feng G,
Hoffmann P,
Propping P,
Vasilescu C,
Maier W,
Rietschel M,
Zammit S,
Schumacher J,
Quinn EM,
Schulze TG,
Williams NM,
Giegling I,
Iwata N,
Ikeda M,
Darvasi A,
Shifman S,
He L,
Duan J,
Sanders AR,
Levinson DF,
Gejman PV,
Cichon S,
Nöthen MM,
Gill M,
Corvin A,
Rujescu D,
Kirov G,
Owen MJ,
Buccola NG,
Mowry BJ,
Freedman R,
Amin F,
Black DW,
Silverman JM,
Byerley WF,
Cloninger CR;
Molecular Genetics of Schizophrenia Collaboration.
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
PMID: 18677311 [PubMed - indexed for MEDLINE]