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deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
PMID: 18264098 [PubMed - indexed for MEDLINE]
Cancer Epidemiol Biomarkers Prev. 2009 Apr; 18(4):1290-4. Epub 2009 Mar 31.
[Cancer Epidemiol Biomarkers Prev. 2009]
J Natl Cancer Inst. 2007 Dec 19; 99(24):1836-44. Epub 2007 Dec 11.
[J Natl Cancer Inst. 2007]
Prostate Cancer Prostatic Dis. 2008; 11(3):241-6. Epub 2007 Sep 18.
[Prostate Cancer Prostatic Dis. 2008]
Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1761-4.
[Cancer Epidemiol Biomarkers Prev. 2006]
Nat Clin Pract Rheumatol. 2008 Apr; 4(4):210-7. Epub 2008 Mar 4.
[Nat Clin Pract Rheumatol. 2008]
Quaye L, Tyrer J, Ramus SJ, Song H, Wozniak E, DiCioccio RA, McGuire V, Høgdall E, Høgdall C, Blaakaer J, et al. PLoS One. 2009 Jun 19; 4(6):e5983. Epub 2009 Jun 19.
[PLoS One. 2009]
Witte JS. Nat Rev Genet. 2009 Feb; 10(2):77-82. Epub 2008 Dec 23.
[Nat Rev Genet. 2009]
Edwards AO, Fridley BL, James KM, Sharma AK, Cunningham JM, Tosakulwong N. PLoS One. 2008; 3(11):e3813. Epub 2008 Nov 26.
[PLoS One. 2008]
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