A public meeting sponsored by the Risk Assessment Consortium.
The interagency Risk Assessment Consortium (RAC) is planning to hold a public meeting on September 28 on the topic "Predicting human dose-response relationships from multiple biological models: Issues with Cryptosporidium parvum." The meeting will be formally announced in the Federal Register at a later date.
The purpose of the meeting is to discuss the use of human and nonhuman models of infection and disease to predict human dose-response relationships for foodborne pathogens. We will focus on the water- and food-borne parasite C. parvum as a model organism for other foodborne pathogens. The meeting will include technical presentations on the epidemiology and biology of C. parvum infections, the different types of biological models being used to estimate dose-response relationships for C. parvum infections, the potential for integrating data from different types of models, and the use of biological data to develop mathematical models of human dose-response relationships. The meeting will also include a presentation, targeted to the public, on the role that dose-response modeling plays in setting food safety policy. In addition, an opportunity for public comment will be provided.
The tentative agenda for the meeting can be seen at the bottom of this page.
When: September 28, 2000, from approximately 8:30 a.m. to 5:30 p.m.
Where: USDA Center at Riverside, Room 1D00 (Conference Center), 4700 River Road, Riverdale MD 20737-1238.
Transportation: The USDA Center at Riverside is located within walking distance (0.8 mile) of the College Park station on Metrorail’s Green Line. There is also Metrobus service and free shuttle service from the College Park Metro station to the Riverdale Center. Parking at the USDA-Riverside Center is limited. Entry into the parking lot costs $2 (exact change required). For more walking, Metro, and driving information/directions, see http://www.aphis.usda.gov/biotech/direct.html or http://www.aphis.usda.gov/oa/aphismap.html.
Registration: Advance registration is required by September 25, 2000. Walk-in registration is strongly discouraged. You may register on-line or send registration information (name, title, affiliation, address, email address, telephone and fax numbers) to Shiho Sasamoto, HFS-006, CFSAN, 200 C St., S.W., Washington, DC 20204, Fax 202-260-1654, Phone 202-205-4355. There is no registration fee. If you need special accommodations due to a disability, please contact Wesley Long at least 7 days in advance.
Public comment: The meeting will include a period for public comments on C. parvum, dose-response modeling, or other issues related to risk assessment. For planning purposes, people who wish to speak during the public comment period must register in advance by contacting Lauren Posnick or Wesley Long.
Additional information: Contact Lauren Posnick, lposnick@cfsan.fda.gov, 202-205-4588, or Wesley Long, 202-205-4024.
Preliminary Agenda
(Please note that titles, speakers, and times are subject to change.)
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8:30 - 9:00 |
Coffee and registration |
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Morning Session I: Introduction and risk communication |
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9:00 - 9:20 |
Welcome and introduction |
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9:20 - 9:45 |
The importance of dose-response modeling to the public (Bill Hallman, Rutgers University) |
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9:45 - 10:10 |
Public comment period |
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10:10 - 10:25 |
Break |
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Morning Session II: Host and parasite factors affecting dose-response models |
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10:25 - 10:30 |
Introduction |
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10:30 - 10:55 |
Host factors affecting C. parvum infection (John Balbus, George Washington University) |
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10:55 - 11:20 |
Parasite factors affecting C. parvum infection (Altaf Lal, Centers for Disease Control) |
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11:20 - 12:30 |
Lunch |
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12:30 - 12:55 |
Host-parasite interactions (Honorine Ward, New England Medical Center) |
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Afternoon Session I: Dose-response models |
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12:55 - 1:05 |
Introduction |
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1:05 - 1:30 |
Animal models (Mike Arrowood, Centers for Disease Control) |
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1:30 - 1:55 |
Cell culture, animal, and human models (Ricardo DeLeon, Metropolitan Water District of Southern California) |
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1:55 - 2:20 |
Cell culture and mouse models (Joan Rose, University of South Florida) |
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2:20 - 2:35 |
Break |
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2:35 - 3:00 |
Animal models (Saul Tzipori, Tufts University) |
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3:00 - 3:25 |
Human models (Cynthia Chappell, University of Texas-Houston) |
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Afternoon Session II: Panel discussion of dose-response modeling |
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3:30 - 5:00 |
Panel Discussion (invited participants include Charles Haas, Drexel University; Jack Colford, University of California at Berkeley-SPH; Mary Alice Smith, University of Georgia; and speakers from Afternoon Session I) |
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5:00 - 5:15 |
Conclusion |