ATSDR - Toxicological Profile: Methylenedianiline

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Toxicological Profile for

Methylenedianiline

CAS# 101-77-9

August 1998

TOXICOLOGICAL PROFILE INFORMATION:

The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Each peer-reviewed profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The complete list of topics covered (chapter titles) is shown at the left and in more detail further down this page.

The focus of the profile is on health and toxicologic information. Therefore, each profile begins with a Public Health Statement that summarizes in nontechnical language, a substance's relevant properties.

A useful two page information sheet, the ToxFAQs ^TM, is also available.

TOXICOLOGICAL PROFILE ACCESS (PDF files):

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TOXICOLOGICAL PROFILE CONTENTS:

The table of contents and list of individual PDF files are given below. The whole profile in one large PDF file is here: PDF File 4.0M

PREFACE    PDF File   500k
             Foreword
             Contributors
             Peer review
             Contents
             List of figures
             List of tables

1. PUBLIC HEALTH STATEMENT     PDF File   200k
       1.1    What is this substance?
       1.2    What happens to it when it enters the environment?
       1.3    How might I be exposed to it?
       1.4    How can it enter and leave my body?
       1.5    How can it affect my health?
       1.6    Is there a medical test to determine whether I have
                     been exposed to it?
       1.7    What recommendations has the federal government
                     made to protect human health?
       1.8    Where can I get more information?

2. HEALTH EFFECTS    PDF File 1.0M
       2.1    Introduction
       2.2    Discussion of health effects by route of exposure
       2.3    Toxicokinetics
       2.4    Mechanisms of action
       2.5    Relevance to public health
       2.6    Biomarkers of exposure and effect
       2.7    Interactions with other substances
       2.8    Populations that are unusually susceptible
       2.9    Methods for reducing toxic effects
       2.10 Adequacy of the database

3. CHEMICAL AND PHYSICAL INFORMATION PDF File 200k
       3.1    Chemical Identity
       3.2    Physical and Chemical Properties

4. PRODUCTION, IMPORT, USE, AND DISPOSAL PDF File 200k
       4.1    Production
       4.2    Import / Export
       4.3    Use
       4.4    Disposal

5. POTENTIAL FOR HUMAN EXPOSURE PDF File 400k
       5.1    Overview
       5.2    Releases to the environment
       5.3    Environmental fate
       5.4    Levels monitored or estimated in the environment
       5.5    General population and occupational exposure
       5.6    Populations with potentially high exposure
       5.7    Adequacy of the database

6. ANALYTICAL METHODS    PDF File   300k
       6.1    Biological materials
       6.2    Environmental samples
       6.3    Adequacy of the database

7. REGULATIONS AND ADVISORIES PDF File 200k

8. REFERENCES PDF File 200k

9. GLOSSARY PDF File 100k

APPENDICES    PDF File   300k
       A.    Minimal risk level worksheets
       B.    User's guide
       C.    Acronyms, abbreviations, and symbols

Reference

Agency for Toxic Substances and Disease Registry (ATSDR). 1998. Toxicological profile for methylenedianiline. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Disclaimer

All ATSDR toxicological profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the toxicological profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the toxicological profile home page , which also contains other important information about the profiles.

Where can I get more information?

ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.

For more information, contact:

Agency for Toxic Substances and Disease Registry
Division of Toxicology
1600 Clifton Road NE, Mailstop E-29
Atlanta, GA 30333
Phone: 1-888-422-8737
FAX: (404)498-0057

ATSDR Information Center / ATSDRIC@cdc.gov / 1-888-422-8737

This page was updated on May 25, 2001