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URL of this page: http://www.genome.gov/10005107 |
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The ENCODE Project: ENCyclopedia Of DNA Elements
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The ENCODE Consortium is composed primarily of scientists who were funded under RFAs released by NHGRI. Other participants have been identified and brought into the Consortium as appropriate. The Consortium is open to any investigator willing to abide by the criteria for participation established for the ENCODE Project by NHGRI. The ENCODE External Consultants Panel oversees the activities of the Consortium and provides advice and feedback on the Consortium's goals, progress and membership.
Those interested in applying for membership to the ENCODE Consortium should review the criteria for participation and contact Elise Feingold, Ph.D., or Peter Good, Ph.D. (See: Program Staff).
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The NHGRI is committed to the principle of rapid data release to the scientific community. This principle was initially implemented during the Human Genome Project and has been recognized as leading to one of the most effective ways of promoting the use of the human genome sequence to advance scientific knowledge.
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The data produced by ENCODE Consortium members are deposited to public databases and are available for all to use without restriction. Data linked to the genomic sequence is stored and visualized on the University of California, Santa Cruz browser at ENCODE Project at UCSC [genome.ucsc.edu]. Other, non-sequence based data, like that from microarray studies, are available on public databases such as the Gene Expression Omnibus (GEO) [ncbi.nlm.nih.gov] and ArrayExpress [ebi.ac.uk]. The NHGRI Division of Intramural Research will be developing a "portal" that will function as a single point of entry from which users can search and retrieve data from the ENCODE Project. Data users should abide by the ENCODE Data Release Policy when accessing data produced by ENCODE Consortium members.
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Common cell types have been identified by the Consortium to aid in the integration and comparison of data produced by ENCODE participants using different technologies and platforms.
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The pilot and technology development phases of the ENCODE project were initiated simultaneously in 2003 when NHGRI released Requests For Application (RFAs) for each of these phases. The first RFA for the pilot phase, RFA HG-03-003, entitled Determination of all functional elements in human DNA, solicited applications from those interested in participating in a research network to conduct a pilot project to test and compare existing methods for identifying all of the functional elements in a limited (~1%) region of the human genome. The second RFA, RFA HG-03-004, entitled Technologies to find functional elements in DNA, solicited applications to develop new and improved technologies for the efficient, comprehensive, high-throughput identification and verification of all types of sequence-based functional elements, particularly those other than coding sequences, for which adequate methods do not currently exist.
NHGRI re-released the technology development RFA in 2004 and 2006. RFA HG-04-001, issued in 2004, solicited additional applications with an added emphasis on high-risk, high-payoff projects and on technologies that might be applied to model organism genomes. RFAs HG-07-028 and HG-07-029, issued in 2006, had an added emphasis on methods to identify functional elements in repetitive sequences and on methods than can be used to validate the identity of functional elements using methods independent of the primary mode of detection.
As the initial phase of the ENCODE Project will be completed in September 2007, NHGRI issued RFAs in November 2006 to solicit application for research projects to continue the ENCODE-based analysis of the human genome at both pilot and whole-genome scales. RFA HG-07-030, entitled Creating the Encyclopedia of DNA Elements (ENCODE) in the Human Genome (U01 and U54), solicited applications for research projects to identify functional elements in the entire human genome sequence (for whole-genome scale projects) or in the 1% of the genome targeted during the ENCODE pilot phase (for pilot-scale projects). RFA HG-07-031, entitled A Data Coordination Center for the Encyclopedia of DNA Elements (ENCODE) Project (U41) solicited applications to develop, house, and maintain databases to track, store, and provide access to the different types of data generated as part of the ENCODE Project.
NOT-07-007: Clarification and Additional Information to HG-07-030 and HG-07-031
Slides from Applicant Information Meeting - HG-07-030
NOT-07-007: Clarification and Additional Information to HG-07-030 and HG-07-031
Slides from Applicant Information Meeting - HG-07-031
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Program Directors
Elise Feingold, Ph.D.
E-mail: feingole@exchange.nih.gov
Peter Good, Ph.D.
E-mail: goodp@mail.nih.gov
Program Analysts
Laura Liefer Dillon, M.S.
E-mail: dillonl@mail.nih.gov
Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Phone:(301) 496-7531
Fax:(301) 480-2770
To view the PDFs on this page, you will need Adobe Reader.
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Last Updated: September 12, 2008