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Sponsors and Collaborators: |
National Institute on Aging (NIA) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Center for Research Resources (NCRR) |
Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00099697 |
The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.
Condition | Intervention |
Aging Obesity Insulin Resistance |
Drug: DHEA |
MedlinePlus related topics: | Obesity |
ChemIDplus related topics: | Insulin Dehydroepiandrosterone sulfate Prasterone |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double-Blind, Placebo Control |
Official Title: | Biologic Effects of DHEA in Humans |
Estimated Enrollment: | 56 |
Study Start Date: | June 2001 |
Estimated Study Completion Date: | February 2004 |
Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA) reduces abdominal visceral fat and protects against insulin resistance. This study was done to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action in humans.
Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids.
Ages Eligible for Study: | 65 Years to 78 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Missouri | |||||
Washington University School of Medicine | |||||
St. Louis, Missouri, United States, 63110 |
National Institute on Aging (NIA) |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
National Center for Research Resources (NCRR) |
Principal Investigator: | John O. Holloszy, MD | Washington University School of Medicine |
Principal Investigator: | Dennis T. Villareal, MD | Washington University School of Medicine |
Study ID Numbers: | AG0013, 5P60AG013629, 5R01AG020076, 5K23RR016191, 3P30DK056341, 5P60DK020579, 2M01RR000036 |
First Received: | December 17, 2004 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00099697 |
Health Authority: | United States: Federal Government |
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