Online Research Resources Developed at NHGRI

Research Projects and Sequence Analysis Tools

• Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)
  A database of mutations that cause Autoimmune Lymphoproliferative Syndrome (ALPS).
  
  
• Breast Cancer Mutation Database
  A central repository for information regarding mutations and polymorphisms in breast cancer susceptibility genes.
  
  
• The NHGRI Dog Genome Project
  A project to develop resources necessary to map and clone canine genes in an effort to utilize dogs as a model system for genetics and cancer research..
  
  
• GeneLink
  A data management system designed to facilitate genetic studies of complex traits.
  
  
• GeneMachine
  An integrated tool that performs both comparative and predictive gene identification techniques in a single run.
  
  
• Histone Sequence Database
  An updated collection of histone-fold containing proteins.
  
  
• Homeodomain Resource
  An annotated collection of non-redundant protein sequences, three-dimensional structures, and genomic information for the homeodomain protein family.
  
  
• Human Chromosome 7 Mapping and Sequencing
  Summaries of the mapping and sequencing of human chromosome 7 being performed by investigators at NHGRI and by collaborators.
  
  
• Lowe Syndrome Mutation Database
  A database of mutations causing Lowe syndrome.
  
  
• Microarray Core Facility
  A set of protocols for making, using, and analyzing data from cDNA microarrays.
  
  
• Pallister-Hall Syndrome Research
  Information for professionals and families caring for or affected by Pallister-Hall Syndrome.
  
  
• WebMCS
  A tool for the detection of multi-species conserved sequences from multiple sequence alignments.
  
  
• X-Linked SCID Mutation Database (IL2RGbase)
  A database of mutations that cause X-linked severe combined immunodeficiency (XSCID or X-SCID).
  
  

Software Available for Download

• ArrayDB 2.0
  A software suite that provides an interactive user interface for the mining and analysis of microarray gene expression data.
  
  
• ComboScreen
  An organizational framework of analytical tools required for the high-throughput screening of clone arrays with pools of probes.
  
  
• eSAGE
  A comprehensive software package for managing and analyzing data generated by Serial Analysis of Gene Expression.
  
  
• GeneLink
  A data management system designed to facilitate genetic studies of complex traits.
  
  
• GeneMachine
  An integrated tool that performs both comparative and predictive gene identification techniques in a single run.
  
  
• Genometric Analysis Simulation Program (G.A.S.P.)
  A software tool that can generate samples of family data based on user specified genetic models.
  
  
• NHGRI::Blastall.pm
  A Perl module that delivers an object-oriented interface to NCBI's BLAST and BLAST utilities.
  
  
• SOOP
  A tool for the design and selection of overgo probes optimized for high-throughput comparative mapping.
  
  
• WebBLAST
  A suite of programs that organizes sequencing data and provides first-pass sequence analysis in the form of BLAST searches.

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Last Reviewed: March 31, 2008