• Understanding PAH/Soot Formation Chemistry in Combustion Systems
• Gas Standards in Support of NASA’s Space Shuttle Monitoring Program
• New Standards for Next-Generation Low-Emission Vehicles
• Development of a New Beryllium Oxide Standard Reference Material

Biomaterials

• 3D Molecular Bioimaging Mass Spectrometry
• Depth Profiling of Drug Eluting Stent Coatings with Cluster SIMS
• Infrared Microscopy with a ZnSe Solid Immersion Lens
• Realtime Chemical Bioimaging: Direct Detection of Chemicals (O2) in Biological Samples
• Ultra-High Resolution Structured-Illumination Microscopy
• Vibrational Spectroscopic Characterization of Model Biomembranes

Chemicals and Allied Products

• NIST Researcher Improves Models for Thermodynamic Properties of Industrially Important Fluids
• NIST Releases a Thermodynamic and Transport Properties Database for Ionic Liquids: ILTHERMO
• The IUPAC International Chemical Identifier (InChI)
• Evaluation and Improvement of Molecular Simulation Methods
• Theoretical Models for the Study of Magnetic Properties in Metallic Nanoparticles
• Advances in Transport Property Modeling

Data and Informatics

• Measuring Pixel Classification Accuracy Using Synthetic Spectrum Images
• ThermoData Engine: New Generation Expert System for Thermodynamic Data Critical Evaluation
• THERMOInternational 2006 Conference held at NIST in Boulder, Colorado
• ThermoML: New IUPAC Standard for Thermodynamic Data Communications
• The NIST Chemistry WebBook

Energy and Environmental Technologies

• Pipeline-Scale Flow Measurement Standards for Natural Gas
• Optimizing the Measurement of Light-Absorbing (Black) Carbon in Atmospheric Aerosols that Impact Regional Climate
• Advanced Distillation curves for Characterizing Complex Liquid Fuels
• Advances in Liquid Fuel Research: Properties of Real Fuels for Aviation, Aerospace and Vehicular Transportation
• Propane as a Thermodynamic Reference Fluid
• NIST Property Models and Data Support the Transition to Hydrogen as a Transportation Fuel
• Application of Specimen Bank Resources to Investigate Tributyltin in the Alaskan Arctic Marine Ecosystem
• NIST Assists NOAA with Bottlenose Dolphin Health Assessments
• An Estimation of Illicit Drugs from Chemical Measurements in Municipal Wastewater
• Development of a New Multi-Nutrient Fertilizer Standard Reference Material
• Standards Development and Measurements to Support Global Climate Change Studies
• Standard Reference Materials for Hexavalent Chromium in Contaminated Soil
• NIST’s New Standard Reference Material for Organic Contaminants in House Dust
• Environmental Specimen Bank Activities
• Method Development for the Simultaneous Quantification of Mercury and Tin Species in Sediment and Tissue SRMs
• Method Development and Measurements of Polybrominated Diphenyl Ethers (PBDEs) in Tissue, Serum, and Sediment SRMs
• SRMs for Contaminants on Air Particulate Matter
• SRMs for Organic Contaminants in Human Serum and Milk
• Improving Measurements with NIST’s Ozone Reference Standard
• Fossil Fuel SRMs Certified for Sulfur, Mercury, and Chlorine
• Simultaneous Determination of Sulfur Isotopic Composition and Concentration in Two High-Elevation Snowpits Using a 33S/36S Double Spike Technique
• Establishing Measurement Traceability for Gaseous Mercury Emissions Monitoring

Forensics and Homeland Security

• Supplying Training and Educational Materials to the Forensic DNA Community
• Examination of Software for Rapid Analysis of Single Source DNA Profiles
• Human Identity Testing: Forensic Application of the Affymetrix Human Mitochondrial Resequencing Array
• Helping to Improve Human Identity Testing: Development of 26 New miniSTR Loci as DNA Markers
• Development of SRM 2372 Human DNA Concentration Standard to Help Assure Accuracy in Forensic Testing
• Validation of Forensic Identity Tests: Concordance Study with MiniFiler and other STR Kits
• Validated Raman Spectral Libraries as a Resource for Chemical Threat Identification
• An Experimental Model of Anthrax in Drinking Water for the Development of Effective Decontamination Procedures
• NIST Develops Ion Mobility Spectrometric Methods for the Trace Detection of Illicit Narcotics
• Automated Mapping of Explosives Particles in C-4 Fingerprints
• Production of Polymer Test Particle Standards by Inkjet Printing
• Smart Standards: Demonstration of Thermochromic Inks in Trace Explosive Metrology
• Evaluation of Oleoresin Capsicum (Pepper Spray) Canisters for Chemical Content and Reliability
• NIST Develops Reference Materials for Trace Explosives Detection
• Determination of Traces of Fissionable Materials using Delayed Neutron Activation Analysis

Food and Nutrition

• Highly Accurate Measurement of Plant Genomic DNA to Improve Genetic Identity Testing of U.S. Export Grains
• Development of SRMs for Botanical Dietary Supplements
• Carrot Extract Standard Reference Material
• Ginkgo biloba Dietary Supplement Standard Reference Materials
• NIST Develops Serum-Based Standard Reference Materials to Assess Nutritional Status
• Development of Multivitamin/Multielement Dietary Supplement SRM

Health and Medical Technologies

• Development of Standards and Methods for Measuring Gene Expression Assay Performance
• Measurement of DNA Adducts for the Assessment of DNA Damage Repair in Cancer
• Measuring Enzyme Activity to Counter the Threat of Drug-Resistant Tuberculosis
• Tools for Measuring the Performance of DNA Microarray Readers
• Microfluidic Separation and Measurement of Biomolecules Using Gradient Elution Moving Boundary Electrophoresis
• Mitochondrial DNA Mutations as Biomarkers of Early Cancer Detection
• Development of a Robust, Quantitative Fluorescence In Situ Measurement System for Cellular Biomolecules
• Quantitative Proteomics: Ovalbumin Detection Using Forward-Phase Protein Microarrays and Suspension Arrays
• Purity Analysis of SRM Cholesterol, Estradiol, Progesterone, and Testosterone Steroids by Proton NMR
• Measuring Shape Changes in Active Membrane Proteins that Correlate to Their Function
• Cancer Nanotechnology: Characterization of Chemical and Biological Coatings on Gold Nanoparticles by Differential Mobility Analysis
• Nanosensor Development: Self-assembly of DNA-Wrapped Carbon Nanotubes for Sensing Applications
• Nanotechnology: Carbon Nanotube and Thiol Tethered ssDNA Interactions on Gold to Improve Nanomanufacturing
• High Throughput Assessment of Nanoparticle Penetration of Skin
• Modeling the Nanoenvironment of Biological Reactions to Enable Greater in vivo Relevance to in vitro Measurements
• Peptide Ion Fragmentation for Proteomics Applications
• NIST Develops Reference Methods and Standard Reference Materials for Clinical Diagnostic Markers
• NIST Develops Reference Methods and Materials for the Determination of Hormones in Human Serum
• Development of Standard Reference Material (SRM) 955c Lead in Caprine Blood
• NIST Renews Benchmark SRMs for Accurate Determinations of Trace Elements in Serum and Liver
• Innovation in Metabolomics: A New Standard Reference Material for Metabolites in Human Plasma
• Metallomics: A Multidisciplinary Approach for the Measurement of Metalloproteins for Health and Disease Markers
• Development of a Measurement Quality Assurance Program to Support Biomarker Discovery for Early Cancer Detection
• Development of Proteomics-Based Methods for Protein Quantification
• Arsenic Species in Frozen Human Urine

Industrial and Analytical Instruments

• Standard Artifacts to Correct for Inherent Fluorometer Instrument-Associated Signal Detection Fluctuation
• Analytical Information Markup Language (AnIML): A Tool to Insure the Usability of Multiple Format Scientific Data Over Time
• High Pressure Standards Based on Compact Piston Gauges
• Reference Values of Gas Viscosity
• Gas Standards Based on Optical Spectroscopies
• High Performance Metal Oxide Nanostructures for Advanced Solid State Chemical Microsensors
• Metrological Shortcomings of Teflon-Based Helium Permeation Leak Artifacts
• Producing and Processing Microsensor Signals to Meet Critical Chemical Monitoring Needs
• Relative Intensity Standards for Raman Spectroscopy
• Development of a New NIST Calibration Service Using the Comparison Method for Vacuum Gauges Spanning the Range 0.65 Pa to 133 kPa
• Atomic Standard of Pressure
• NIST Uses Inkjet Printing Technology to Produce Standards for Trace Level Explosive Analysis
• Large Angular Convergence Scanned Beam Illumination (LACSBI): Incoherent Imaging for Conventional TEM
• NIST Develops a Transition Edge Sensor Microcalorimeter for Quantitative Analysis
• Innovations in Proteomics: Reference Library of Peptide Ion Fragmentation Spectra for MS Users
• Automatic Mass Spectral Deconvolution and Identification Software (AMDIS)
• Upgrades for Cold Neutron Beam Facilities

Microelectronics

• Process Models and Metrologies for Atomic Layer Deposition
• Non-Contact Free Carrier Density Measurements for Compound Semiconductors
• NIST Develops a High Performance Secondary Ion Mass Spectrometric Method to Search for Particulate Nuclear Material Over Large Areas
• Measurement of Uranium Isotopic Composition with High Sensitivity and Specificity by Secondary Ion Mass Spectrometry
• Molecular Electronics: Charge Transport in Molecular Thin Films on Oxide and Metallic Surfaces
• Study of the Potential Dependence of Co-Adsorption of PEG, Cl-, and SPS/MPS on Cu using In-Situ Spectroscopic Ellipsometry
• Tracing Electronic Pathways in Molecules Using Inelastic Electron Tunneling Spectroscopy
• Molecular Electronics: Structural Contribution to Charge Transport across Ni-Octanedithiol Multilayer Junctions
• NIST Develops Algorithm for Robust Spectral Quantification of Large Particle Data Sets
• New Silicon Drift Detector Technology Enables High-speed Energy Dispersive X-ray Spectrometry
• Nanoscale Electronic Structure Measurements in Organic Systems
• High-Accuracy Measurement of SiGe Chips by Inductively Coupled Plasma Optical Emission Spectroscopy
• NIST Supports Industry Compliance with the EU Directive on Restriction of Certain Hazardous Substances (RoHS)

Measurement Science for Future Standards and Technologies

• Influencing the "Injection Barriers" into Prototype Molecular Wires through Metal-molecule Coupling
• Fitting of Auger Electron and Secondary Electron Line Scans with the Extended Logistic Function
• Properties and Processes for Cryogenic Refrigeration
• Transmission Errors in Magnetic Suspension Densimeters
• Absolute, On-Line Measurement of the Total Alkalinity of Seawater: A Tool for Evaluation of Global Climate Change Mediation Technologies for CO2
• Imaging the Heart of a Cell: Hydrogen Fuel Cells and Nanomedicine
• In vitro Synthesis of Stable Isotopically Labeled Proteins for Use as Internal Standards for Mass Spectrometric Quantitation of Clinical Protein Biomarkers
• Molecular Simulation of Alkylsilane Stationary Phases in Liquid Chromatography

Measurement Standards

• Quantitative Determination of Carbon and Nitrogen Using the Electron Microprobe
• NIST Obtains the World’s First Aberration-corrected, Monochromated Analytical Electron Microscope
• CCQM Activities in the Gas Analysis Working Group
• CCQM Activities in the Inorganic and Electrochemical Analysis Working Groups
• CCQM Activities in the Organic Analysis Working Group
• Traceable Calibrations Gases: SRMs, NTRMs, and EPA Protocol Gases

Pharmaceuticals and Biomanufacturing

• Introducing the New Version Biological Macromolecular Crystallization Database (BMCD4)
• NIST Biomolecular Crystallization Database (BMCD): Adenylyl Cyclase Structure and Mechanism Measurements
• Collagen Thin Films for Improved Nanoscale Mechanical Properties in Cellular Measurement Assays
• A Prototype System for Measuring Thermodynamic Energy to Predict the Affinity of DNA Probes Used For Genetic Testing
• Drug-Binding Database: A Tool for Developing and Evaluating Algorithms Used to Select New Drug Candidates
• Measuring the Thermodynamics of Enzyme Reactions to Enable Better Manufacturing of Biotechnology Products
• Microfluidic System for More Physiologically-Relevant In Vitro Measurement of Cell Function
• Enhancing the Quantitative Capabilities of Surface Plasmon Resonance Spectroscopy
• Spectroscopy Tools to Measure Protein Folding: Correlating Structure and Function
• A New Manufacturing Process for Non-Toxic, Silicone Photoluminescence Nano-Crystal Quantum Dots with Defined Spectral Properties
• Modeling Individual Cell Variability to Improve Quantitative Measurements in Cell-Based Assays
• Unambiguous Chemical Database Searching with Chem-BLAST to Facilitate New Drug Development
• A High-Accuracy Fluorescence Spectrometer and Standard Reference Materials for True Fluorescence Spectra to Enable Quantitative Fluorometry
• A Multistate Model for the Fluorescence Response of R-Phycoerythrin
• Broadband Coherent anti-Stokes Raman Spectroscopy Characterization of Polymer Thin Films

View Projects for FY 2005