Inclusion Criteria :

• Healthy adult aged 18 to 40 years on the day of inclusion.
• Provides signed informed consent prior to study procedures.
• Able to attend all scheduled visits and comply with all trial procedures.
• For a woman of child-bearing potential, avoid becoming pregnant (use of an effective method of contraception or abstinence) for at least 4 weeks prior to the first vaccination, until at least 4 weeks after last vaccination.

Exclusion Criteria :

• Known systemic hypersensitivity to any of the vaccine components or history of a life-threatening reaction to the standard-dose Fluzone® vaccine or to a vaccine containing any of the same substances
• For a woman of child-bearing potential, known pregnancy or positive serum/urine pregnancy test
• Breast feeding woman
• Participation in another clinical trial investigating a vaccine, drug, medical device, or a medical procedure in the 4 weeks preceding the (first) trial vaccination
• Planned participation in another clinical trial during the present trial period
• Known or suspected congenital or acquired immunodeficiency, immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the preceding 6 months, oral, parenteral, or inhaled steroids
• Has an acute or chronic medical illness or any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or would interfere with the evaluation of responses or render the subject unable to meet the requirements of the protocol
• Known or suspected current alcohol abuse or drug addiction that may interfere with the subject's ability to comply with trial procedures
• History of receipt of blood or immunoglobulin or other blood-derived products within the 3 months prior to enrollment in this study that might interfere with the assessment of immune response
• Receipt of any vaccine in the 4 weeks preceding the first trial vaccination
• Planned receipt of any vaccine in the 4 weeks preceding or following any trial vaccination
• Known Human Immunodeficiency Virus (HIV), HBs antigen, or Hepatitis C seropositivity
• Personal or family history of Guillain-Barré Syndrome
• Thrombocytopenia, bleeding disorder or anticoagulants in the 3 weeks preceding inclusion contraindicating IM vaccination
• Active neoplastic disease or a history of any hematologic malignancy
• Previous participation in a pandemic flu trial
• History of H5N1 infection or exposure to presumed/confirmed H5N1 human/animal cases
• Known seizure/epilepsy history and/or taking anti-seizure medication
• Receipt of psychiatric drugs. Subjects receiving a single antidepressant drug and stable for at least 3 months prior to enrollment, without decompensating symptoms will be allowed to enroll in the study.
• Subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent.