Diagnostic Value of HS-CRP in Stable Angina. - Full Text View

Sponsored by:	Shiraz University of Medical Sciences
Information provided by:	Shiraz University of Medical Sciences
ClinicalTrials.gov Identifier:	NCT00719992

Purpose

The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard. The investigators concluded that HS-CRP can be used as a single predictor of coronary vessel involvement in patients with stable angina and positive ETT.

Condition	Intervention
Stable Angina Positive ETT	Procedure: coronary angiography

MedlinePlus related topics: Angina Coronary Artery Disease Exercise and Physical Fitness

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Diagnostic, Non-Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Uncontrolled, Parallel Assignment, Efficacy Study
Official Title:	Diagnostic Value of HS-CRP in Stable Angina Patients With Positive Exercise Test as Compared With Coronary Angiography.

Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:

significant coronary lesion [ Designated as safety issue: No ]

Secondary Outcome Measures:

severity of CAD [ Designated as safety issue: No ]

Enrollment:	97
Study Start Date:	April 2006
Study Completion Date:	August 2007
Primary Completion Date:	August 2007 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental positive ETT, High HS-CRP	Procedure: coronary angiography effect of level of HS-CRP
2: Active Comparator positive ETT, Low HS-CRP	Procedure: coronary angiography effect of level of HS-CRP

Detailed Description:

the investigators included 97 patients with positive ETT and stable angina and saw that Hs-CRP is the only predictor of severity of CAD as compared with coronary angiography in stable angina patients.

Eligibility

Ages Eligible for Study:	43 Years to 64 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Stable angina
Positive ETT

Exclusion Criteria:

Unability to perform ETT
Contraindications for ETT and angiography study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00719992

Locations

Iran, Islamic Republic of, Fars
Cardiology Ward Shiraz University of Medical Sciences
shiraz, Fars, Iran, Islamic Republic of, 51318

Sponsors and Collaborators

Shiraz University of Medical Sciences

Investigators

Study Director:

javad kojuri, M.D.

Shiraz University of Medical Sciences

More Information

Responsible Party:	Shiraz University of medical sciences ( Dr Javad Kojuri )
Study ID Numbers:	4543
Study First Received:	July 18, 2008
Last Updated:	July 18, 2008
ClinicalTrials.gov Identifier:	NCT00719992
Health Authority:	Iran: Ministry of Health

Keywords provided by Shiraz University of Medical Sciences:

Exercise tolerance test
HS-CRP
Coronary angiography
Patients

Study placed in the following topic categories:

Signs and Symptoms
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Angina Pectoris
Pain
Ischemia
Chest Pain

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 13, 2009