Practice parameter for the diagnosis and management of primary immunodeficiency (Algorithm 1)

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1-10. Undefined immunodeficiency or other problem 1-11. Proceed to referral/therapy. (Algorithm 6) 1-9. Is there a celluar or combined defect? (Algorithm 3) 1-8. Is there a phagocyte defect? (Algorithm 4) 1-7. Is there complement deficiency? (Algorithm 5) 1-6. Is there an antibody deficiency? (Algorithm 2) 1-5. Emergency! Proceed immediately to referral 1-1. Suspected primary immunodeficiency 1-4. SCID a possibility? 1-2. Sinopulmonary bacterial infections only? 1-3. Are there: a. Neisserial infections? b. Abscesses and/or fungi? c. i. Atypical mycobacteria? ii. Disseminatedinfection? iii. Opportunistic infection? Source: Joint Council of Allergy, Asthma and Immunology. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2005 May;94:S1-63. All copyrights are reserved by the Joint Council of Allergy, Asthma and Immunology. Practice parameter for the diagnosis and management of primary immunodeficiency (Algorithm 1)