Effect of NAC on Sleep Apnea

This study is not yet open for participant recruitment.

Verified by Assaf-Harofeh Medical Center, May 2007

Sponsored by:	Assaf-Harofeh Medical Center
Information provided by:	Assaf-Harofeh Medical Center
ClinicalTrials.gov Identifier:	NCT00592618

Purpose

Sleep studies in ESRD patients have identified increased prevalence of Sleep Apnea. Based on current knowledge, treatment aimed at reducing oxidative stress might improve Sleep Apnea in HD patients. The aim of our study is to investigate the effect of N-acetylsysteine on Sleep Apnea in HD patients.

Condition	Intervention
ESRD Sleep Apnea	Drug: Oral N-Acetylcysteine 1200 mg x 2/day for 4 weeks

MedlinePlus related topics: Sleep Apnea

Drug Information available for: Acetylcysteine

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Open Label, Active Control, Single Group Assignment, Safety Study

Further study details as provided by Assaf-Harofeh Medical Center:

Show Detailed Description

Eligibility

Ages Eligible for Study:	20 Years to 85 Years
Genders Eligible for Study:	Both

Criteria

Inclusion Criteria:

The study will include 20 patients with ESRD, treated with chronic hemodialysis in Assaf Harofeh Medical Center and suffering from sleep disturbances, such as frequent arousals, snoring, daytime sleepiness.

Exclusion Criteria:

Patients will be excluded from the study if they are:

Recently started treated with chronic dialysis: less than 3 months.
Survived recent major illness, requiring hospitalisation in the last 3 months.
Patients with acute renal failure
Currently treated with antioxidants ( NAC, vitamin E ets.)
Current use of sleep pills

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00592618

Contacts

Contact: Leonid S Feldman, MD

+972-8-9779383

leonidf@asaf.health.gov.il

Locations

Israel
Nephrology Division, Assaf Harofeh Medical Center
Zerifin, Israel, 70300

Sponsors and Collaborators

Assaf-Harofeh Medical Center

Investigators

Principal Investigator:

Leonid S Feldman, MD

Assaf Harofeh MC

More Information

Study ID Numbers:	346147SLEEP
Study First Received:	January 1, 2008
Last Updated:	January 11, 2008
ClinicalTrials.gov Identifier:	NCT00592618
Health Authority:	Israel: Ministry of Health

Keywords provided by Assaf-Harofeh Medical Center:

ESRD
Hemodialysis
Sleep Apnea
Hemodialysis

Study placed in the following topic categories:

Signs and Symptoms
Sleep Apnea Syndromes
Respiratory Tract Diseases
Apnea
Respiration Disorders
Acetylcysteine

Dyssomnias
Sleep Disorders
Signs and Symptoms, Respiratory
N-monoacetylcystine
Sleep Disorders, Intrinsic

Additional relevant MeSH terms:

Respiratory System Agents
Anti-Infective Agents
Antioxidants
Molecular Mechanisms of Pharmacological Action
Nervous System Diseases
Physiological Effects of Drugs
Antiviral Agents

Protective Agents
Pharmacologic Actions
Expectorants
Therapeutic Uses
Free Radical Scavengers
Antidotes

ClinicalTrials.gov processed this record on January 16, 2009