The Serotonergic Transmitter System in Dementia and Affective Disorders

This study is currently recruiting participants.

Verified by Rigshospitalet, Denmark, September 2005

Sponsored by:	Rigshospitalet, Denmark
Information provided by:	Rigshospitalet, Denmark
ClinicalTrials.gov Identifier:	NCT00192998

Purpose

The aim of this project is to examine the serotonergic transmitter system using functional imaging of the brain (positron emission tomography [PET]) to gain knowledge about early pathophysiological changes in Alzheimer's dementia and mood disorders.

Condition
Mood Disorders Alzheimer Disease

Genetics Home Reference related topics: Alzheimer disease

MedlinePlus related topics: Alzheimer's Disease Dementia

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Prospective Study

Further study details as provided by Rigshospitalet, Denmark:

Estimated Enrollment:	100
Study Start Date:	October 2003

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Moderate to severe Alzheimer's disease
Individuals genetically predisposed to affective disorder
Healthy gender and age matched controls

Exclusion Criteria:

Contraindications to magnetic resonance imaging (MRI)
Use of psychoactive drugs
Past or present affective disorder
Other systemic diseases that may affect brain function

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00192998

Contacts

Contact: Vibe G. Frokjaer, MD	+45 3545 6714	vibe@nru.dk
Contact: Steen G. Hasselbalch, MD		sgh@nru.dk

Locations

Denmark
Neurobiological Research Unit	Recruiting
Copenhagen, Denmark, 2100
Contact: Vibe G. Frokjaer, MD +45 3545 6714 vibe@nru.dk
Principal Investigator: Vibe G. Frokjaer, MD

Sponsors and Collaborators

Rigshospitalet, Denmark

Investigators

Principal Investigator:

Vibe G. Frokjaer, MD

Neurobiological Research Unit, Copenhagen University Hospital, Denmark

More Information

homepage for the neurobiological research unit, Copenhagen, Denmark This link exits the ClinicalTrials.gov site

Study ID Numbers:	SERT-AD
Study First Received:	September 13, 2005
Last Updated:	September 26, 2007
ClinicalTrials.gov Identifier:	NCT00192998
Health Authority:	Denmark: Ethics Committee

Keywords provided by Rigshospitalet, Denmark:

Affective disorder
Alzheimer dementia
healthy controls

Study placed in the following topic categories:

Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Alzheimer Disease
Mood Disorders
Central Nervous System Diseases
Healthy

Neurodegenerative Diseases
Brain Diseases
Dementia
Cognition Disorders
Delirium

Additional relevant MeSH terms:

Pathologic Processes
Disease
Nervous System Diseases
Tauopathies

ClinicalTrials.gov processed this record on January 15, 2009