Regenerative Endodontic Techniques - Full Text View

Sponsored by:	The University of Texas Health Science Center at San Antonio
Information provided by:	The University of Texas Health Science Center at San Antonio
ClinicalTrials.gov Identifier:	NCT00595595

Purpose

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.

Condition
Regenerative Endodontic Tissue Engineering Dental Pulp Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Cross-Sectional
Official Title:	Development of a Model to Evaluate Regenerative Endodontic Techniques

Further study details as provided by The University of Texas Health Science Center at San Antonio:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

extracted teeth 10ml of blood for DNA banking

Estimated Enrollment:	1080
Study Start Date:	February 2007
Estimated Study Completion Date:	February 2009
Estimated Primary Completion Date:	February 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts
1
2

Detailed Description:

The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.

Eligibility

Ages Eligible for Study:	16 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Patients presenting for surgical removal of impacted teeth

Criteria

Inclusion Criteria:

Pre-existing indication for surgical extraction of impacted teeth
Age 16-65

Exclusion Criteria:

Ages less than 16 or over 65
No pre-existing indication for surgical extraction of impacted teeth

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00595595

Locations

United States, Texas
The University of Texas Health Science Center at San Antonio	Recruiting
San Antonio, Texas, United States, 78229
Contact: Kenneth M. Hargreaves, DDS, PhD 210-567-3385 Hargreaves@uthscsa.edu
Contact: Erin Locke, RN, BSN 210-567-0895 Locke@uthscsa.edu
Principal Investigator: Kenneth M. Hargreaves, DDS, PhD
Sub-Investigator: Karl Keiser, DDS, MS

Sponsors and Collaborators

The University of Texas Health Science Center at San Antonio

Investigators

Principal Investigator:

Kenneth M Hargreaves, DDS, PhD

University of Texas

More Information

Responsible Party:	University of Texas Health Science Center at San Antonio ( Kenneth M. Hargreaves )
Study ID Numbers:	HSC20070149H
Study First Received:	January 7, 2008
Last Updated:	July 18, 2008
ClinicalTrials.gov Identifier:	NCT00595595
Health Authority:	United States: Institutional Review Board

Keywords provided by The University of Texas Health Science Center at San Antonio:

Dental Pulp
Regenerative Medicine
Odontoblasts

Stem Cells
Growth factor differentiation of stem/progenitor cells
Odontoblast-specific cell phenotypes

Study placed in the following topic categories:

Tooth Diseases
Dental Pulp Diseases
Stomatognathic Diseases

ClinicalTrials.gov processed this record on January 16, 2009