The Effect of Long-Chain Polyunsaturated Fatty Acids on Cognitive Performance and Mood - Full Text View

Sponsors and Collaborators:	University of Ulm Philipps University Marburg Medical Center Cognitive Drug Research Ltd
Information provided by:	University of Ulm
ClinicalTrials.gov Identifier:	NCT00615277

Purpose

The study investigates whether dietary intake of omega-3 long-chain polyunsaturated fatty acids affects learning and mood of healthy young adults.

Condition	Intervention
Healthy	Dietary Supplement: Omega-3 fatty acids

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Basic Science, Randomized, Double Blind (Subject, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment
Official Title:	The Effect of Long-Chain Polyunsaturated Fatty Acids on Cognitive Performance and Mood of Healthy Young Adults

Further study details as provided by University of Ulm:

Primary Outcome Measures:

Cognition [ Time Frame: Before intervention and after 16 weeks of intervention ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Mood [ Time Frame: Before intervention and after 16 weeks of intervention ] [ Designated as safety issue: No ]

Enrollment:	82
Study Start Date:	October 2006
Primary Completion Date:	January 2007 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Active Comparator 1: omega-3 fatty acid supplement	Dietary Supplement: Omega-3 fatty acids 600 mg EPA 120mg DHA daily, 16 weeks
2: Placebo Comparator 2: olive oil	Dietary Supplement: Omega-3 fatty acids 600 mg EPA 120mg DHA daily, 16 weeks

Detailed Description:

The long-chain polyunsaturated fatty acids (LCPUFA) EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) of the omega-3 series and AA (arachidonic acid) of the omega-6 series are building blocks of all cell membranes and are found in high concentrations in retina and brain. Food sources of LA and ALA are vegetable oils, nuts and seeds. Since low conversion rates from ALA to DHA are a characteristic of human metabolism, adequate dietary provision with the long-chained omega-3 molecules depends primarily on individual eating habits. While AA is abundant in meat and dairy products, EPA and DHA are found in noteworthy concentrations only in certain species of fatty fish, such as salmon or mackerel.

The study investigates whether participants receiving an omega-3 supplement over a period of 4 month, perform better on a series of cognitive tests, than the participants allocated to the placebo group.

Eligibility

Ages Eligible for Study:	16 Years to 24 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy young adults

Exclusion Criteria:

Coagulation disorder

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00615277

Sponsors and Collaborators

University of Ulm

Philipps University Marburg Medical Center

Cognitive Drug Research Ltd

Investigators

Principal Investigator:	Katharina A Widenhorn-Mueller, PhD	University of Ulm
Principal Investigator:	Ulrike Weiland, MD	University of Ulm

More Information

Responsible Party:	University of Ulm ( Prof. Dr. Dr. Manfred Spitzer )
Study ID Numbers:	213/2005, 213/2005
Study First Received:	February 1, 2008
Last Updated:	February 13, 2008
ClinicalTrials.gov Identifier:	NCT00615277
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Ulm:

Young adults
Long-chain polyunsaturated fatty acids
Cognitive function
Mood
Supply with omega-3 fatty acids

Study placed in the following topic categories:

Healthy

ClinicalTrials.gov processed this record on January 14, 2009