Dissecting Cancer Pathways using the Zebrafish: Autophagy and CHK1-Suppressed Apoptosis (NIH-Only) |
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| Launch in standalone player | |
| Air date: | Tuesday, April 29, 2008, 8:00:00 AM |
| Category: | NCI CCR Grand Rounds (NIH Only) |
| Description: | Center for Cancer Research - National Cancer Institute Grand Rounds
Dr. Look received his M.D. degree and postgraduate training in Pediatrics from the University of Michigan, in Ann Arbor, Michigan, and his fellowship training in Pediatric Oncology at St. Jude Children's Research Hospital in Memphis, Tennessee. He then accepted a faculty position at St. Jude, and remained on the faculty for 20 years, ultimately becoming the Chair of the Experimental Oncology Department at St. Jude Children's Research Hospital. In June of 1999, he joined the Dana-Farber Cancer Institute in Boston, Massachusetts as Vice-Chair for Research in Pediatric Oncology and Professor of Pediatrics at Harvard Medical School. Research in his laboratory focuses on the molecular pathogenesis of leukemia, and has resulted in the identification and functional analysis of several chimeric oncogenes activated by chromosomal translocation, including the discovery that E2A-HLF transcription factor acts through an evolutionarily conserved pathway to promote leukemia cell survival. His work in human T-cell acute lymphoblastic leukemia has led to the identification of five multistep mutational pathways and the discovery that NOTCH1 receptors are mutationally activated in the majority of patients with this disease. His recent work led to the first transgenic model of leukemia in the zebrafish, paving the way for chemical and genome-wide genetic modifier screens in a vertebrate disease model. The primary educational objective of these seminars is to provide new information, ideas, and discussion about timely areas of research with impact on the field of oncology. A secondary educational objective is to elicit participation by individuals from all divisions of the intramural NCI, and thus facilitate more interactions among investigators and groups in the NCI. |
| Author: | A. Thomas Look, M.D., Harvard Medical School |
| Runtime: | 00:54:48 |
| CIT File ID: | 14456 |
| CIT Live ID: | 6684 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14456 |