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Sponsors and Collaborators: |
UMC Utrecht De Hersenstichting (The Dutch Brain Foundation) |
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Information provided by: | UMC Utrecht |
ClinicalTrials.gov Identifier: | NCT00161161 |
Attention Deficit Hyperactivity Disorder (ADHD) is a heritable psychiatric disorder with onset in childhood. Twin and adoption studies indicate that additive genetic factors explain up to 80% of the variance underlying susceptibility. The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects, and the risk is even greater for monozygotic twins with 50-80% concordance compared with up to 33% in dizygotic twins). As full siblings share on average 50% of their genes, even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder. The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies. Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5% in these children. In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings, as well as control subjects. In addition, cheekswabs were later collected for DNA analysis.
Condition |
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Attention Deficit Hyperactivity Disorder |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Case Control, Prospective Study |
Official Title: | Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder |
Ages Eligible for Study: | 7 Years to 18 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Inclusion criteria for patients
Inclusion criteria for siblings
Inclusion criteria for controls
Exclusion Criteria:
Netherlands | |
UMC Utrecht | |
Utrecht, Netherlands, 3584CX |
Principal Investigator: | Sarah Durston, Ph.D. | RMI of Neuroscience, UMC Utrecht |
Study ID Numbers: | WOM 99/076 |
Study First Received: | September 8, 2005 |
Last Updated: | December 29, 2005 |
ClinicalTrials.gov Identifier: | NCT00161161 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
ADHD; MRI; genetics |
Signs and Symptoms Attention Deficit Disorder with Hyperactivity Mental Disorders Mental Disorders Diagnosed in Childhood |
Neurologic Manifestations Attention Deficit and Disruptive Behavior Disorders Hyperkinesis Dyskinesias |
Pathologic Processes Disease Nervous System Diseases |