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Sponsored by: |
University of Florida |
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Information provided by: | University of Florida |
ClinicalTrials.gov Identifier: | NCT00160758 |
This purpose of this study is to measure the strength of tissue allografts that have been in the body various lengths of time.
Condition | Intervention | Phase |
---|---|---|
Bone Cancer |
Procedure: retrieve massive allograft |
Phase IV |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Physical Characteristics of Retrieved Massive Allografts |
Estimated Enrollment: | 30 |
Study Start Date: | December 1999 |
Allograft bone is the primary source of graft material for large skeletal defects resulting from trauma, disease, oncological resection, or reconstruction of failed total joint arthroplasties. The physical characteristics of such grafts after various intervals of remodeling and incorporation in vivo have never been studied.
The purpose of this study is to obtain tissue from allografts retrieved at autopsy, at amputation for oncological complications and from patients undergoing revision procedures for failed allograft transplantation. We will evaluate the mechanical properties, histomophometric indices and presence of microfractures.
Our hypotheses are:
The retrieved tissue will be processed using standard undecalcified histology and quantitatively assessed for degree of incorporation, allograft porosity, and microfracture density. The biomechanical characteristics of the bulk allograft and allograft-host junction will be quantified and compared to allograft bone prior to transplantation.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Mark T. Scarborough, M.D. | 352-273-7002 | scarbmt@ortho.ufl.edu |
United States, Florida | |
UF Orthopaedics and Sports Medicine Institute | Recruiting |
Gainesville, Florida, United States, 32611 | |
Contact: Darlene E. Bailey 352-273-7073 bailede@ortho.ufl.edu | |
Principal Investigator: Mark T. Scarborough, M.D. |
Principal Investigator: | Mark T. Scarborough, M.D. | University of Florida |
Study ID Numbers: | 214-1999 |
Study First Received: | September 8, 2005 |
Last Updated: | May 9, 2008 |
ClinicalTrials.gov Identifier: | NCT00160758 |
Health Authority: | United States: Institutional Review Board |
Musculoskeletal Diseases Bone Neoplasms Bone neoplasms Bone Diseases |
Neoplasms Neoplasms by Site |