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Sponsored by: |
Radboud University |
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Information provided by: | Radboud University |
ClinicalTrials.gov Identifier: | NCT00160056 |
Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration. The loss of autonomic symptoms to hypoglycemia does not solely depend on loss of adrenaline responses.Differences in sensitivity to catecholamines may also be involved.
Reconciling the data on β2-adrenergic receptor polymorphism to those on loss of β-adrenergic sensitivity in diabetic patients with hypoglycemia unawareness, we hypothesize that hypoglycemia unawareness is at least partly the result of desensitization of the β2-adrenergic receptor and that patients who are homozygous for arginine at codon 16 are particularly susceptible for this desensitization process, whereas patients who are homozygous for glycine at codon 16 are resistant for desensitization.
Objectives
Condition | Intervention |
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Diabetes Hypoglycemia Unawareness |
Procedure: Hypoglycemia |
Study Type: | Interventional |
Study Design: | Diagnostic, Randomized, Single Blind, Placebo Control, Crossover Assignment |
Official Title: | The Effect of Antecedent Hypoglycaemia on β2-Adrenergic Sensitivity in Subjects With Homozygous Arg16 and gly16 Polymorphism of the β2-Adrenergic Receptor |
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Netherlands, Gelderland | |
Radboud University Nijmegen Medical Centre | |
Nijmegen, Gelderland, Netherlands, 6500HB |
Principal Investigator: | Paul Smits, PhD, MD | Radboud University |
Study ID Numbers: | HB2-001 |
Study First Received: | September 9, 2005 |
Last Updated: | February 28, 2007 |
ClinicalTrials.gov Identifier: | NCT00160056 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
Hypoglycemia unawareness Diabetes adrenal receptor |
adrenerg respons adrenergic beta-agonists salbutamol |
Metabolic Diseases Albuterol Diabetes Mellitus Epinephrine |
Metabolic disorder Glucose Metabolism Disorders Hypoglycemia |