Genetic Analysis of Thyrotoxic Periodic Paralysis - Full Text View

Sponsored by:	Ramathibodi Hospital
Information provided by:	Ramathibodi Hospital
ClinicalTrials.gov Identifier:	NCT00443833

Purpose

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Condition
Thyrotoxic Periodic Paralysis

MedlinePlus related topics: Paralysis

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Case Control, Retrospective Study
Official Title:	Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

Further study details as provided by Ramathibodi Hospital:

Estimated Enrollment:	80
Study Start Date:	January 2004
Estimated Study Completion Date:	December 2005

Detailed Description:

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

Eligibility

Ages Eligible for Study:	15 Years and older
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

TPP

Hyperthyroid patients from any causes
Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)
Episodic paralysis

Exclusion Criteria:

Hypokalemia from GI or renal loss

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00443833

Sponsors and Collaborators

Ramathibodi Hospital

Investigators

Principal Investigator:

Wallaya Jongjaroenprasert, MD

Endocrinology Unit, Ramathibodi Hospital, Mahidol University

More Information

Study ID Numbers:	11-46-21
Study First Received:	March 5, 2007
Last Updated:	March 5, 2007
ClinicalTrials.gov Identifier:	NCT00443833
Health Authority:	Thailand: Ethical Committee

Keywords provided by Ramathibodi Hospital:

Thyrotoxicosis
genetic association study
periodic paralysis
whole genome scan

Study placed in the following topic categories:

Paralysis
Signs and Symptoms
Metabolism, Inborn Errors
Metabolic Diseases
Muscular Diseases
Paralyses, Familial Periodic

Genetic Diseases, Inborn
Neuromuscular Diseases
Musculoskeletal Diseases
Neurologic Manifestations
Metabolic disorder

Additional relevant MeSH terms:

Nervous System Diseases
Metal Metabolism, Inborn Errors

ClinicalTrials.gov processed this record on January 16, 2009