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Sponsors and Collaborators: |
Synvista Therapeutics, Inc National Institutes of Health (NIH) National Heart and Lung Institute |
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Information provided by: | Synvista Therapeutics, Inc |
ClinicalTrials.gov Identifier: | NCT00302250 |
The primary objective of the double-blind segment is to compare effects of alagebrium vs placebo on change from baseline in endothelial function, as assessed by flow-mediated vasodilation (FMD).
Condition | Intervention | Phase |
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Cardiovascular Disease |
Drug: ALT-711 (alagebrium chloride) |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Pharmacodynamics Study |
Official Title: | Study of The Effect of Vascular Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension Before and After Receiving Oral Alagebrium or Placebo for 8 Weeks (STRETCH) |
Estimated Enrollment: | 70 |
Study Start Date: | February 2006 |
Estimated Study Completion Date: | December 2006 |
The secondary objectives of the double-blind segment are to:
Ages Eligible for Study: | 50 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Maryland | |
Johns Hopkins University School of Medicine | |
Baltimore, Maryland, United States, 21287 |
Principal Investigator: | Susan Zieman, MD, PhD | Johns Hopkins University |
Study ID Numbers: | ALT-711-0217 (Amended) |
Study First Received: | March 13, 2006 |
Last Updated: | March 21, 2006 |
ClinicalTrials.gov Identifier: | NCT00302250 |
Health Authority: | United States: Food and Drug Administration |
Cardiovascular Flow-mediated vasodilation (FMD) Pulse perfusion-mediated vasodilation (PPMV) Endothelial function Heart failure |
Heart Failure Vascular Diseases Hypertension |
Cardiovascular Diseases |