Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic Disease - Full Text View

Sponsors and Collaborators:	Centre Hospitalier Universitaire de Nice ADPHUN, FRM
Information provided by:	Centre Hospitalier Universitaire de Nice
ClinicalTrials.gov Identifier:	NCT00569361

Purpose

Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups:

allergic rhinitis to dust mite (AR) isolated (n=12),
AR associated with bronchial hyperreactivity (n=12),
AR associated with asthma (n=14),
control (n=14).

Condition	Intervention
Allergic Rhinitis	Procedure: Collection of nasal epithelial cells

MedlinePlus related topics: Asthma

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Screening, Open Label, Single Group Assignment, Efficacy Study
Official Title:	Nasal Epithelium Gene Expression Profiling in Child Respiratory Allergic

Further study details as provided by Centre Hospitalier Universitaire de Nice:

Primary Outcome Measures:

Transcriptome analysis: genes statistically modulated between groups, predictive biomarkers allowing correct classification of groups [ Time Frame: At the sample time ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Validation with other techniques: Q-PCR [ Time Frame: At the sample time ] [ Designated as safety issue: No ]

Enrollment:	80
Study Start Date:	November 2004
Study Completion Date:	October 2005

Arms	Assigned Interventions
A Collection of nasal epithelial cells by brushing	Procedure: Collection of nasal epithelial cells Collection of nasal epithelial cells by brushing

Detailed Description:

Context: Asthma is the most frequent chronic disease in childhood. Allergic rhinitis has been described as a risk factor to develop asthma. The objective of the study was to evaluate the contribution of the respiratory epithelium to development of allergic rhinitis and asthma and to identify the molecular mechanisms driving rhinitis toward asthma.

Methods: Using a human pangenomic microarray, we established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct children 2 to 18 years of age groups:

allergic rhinitis to dust mite (AR) isolated (n=12),
AR associated with bronchial hyperreactivity (n=12),
AR associated with asthma (n=14),
control (n=14).

Eligibility

Ages Eligible for Study:	6 Years to 17 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients:

Patients between 6 and 17 years old
Patients with allergic rhinitis

Witness:

Patients between 6 and 17 years old
Patients without allergic rhinitis and asthma

Exclusion Criteria:

Rhino-bronchitis infection dated from less than 15 days
Patients younger than 6 or older than 17 years

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00569361

Locations

France
Department of Pediatrics, Nice University Hospital
Nice, France, 06000

Sponsors and Collaborators

Centre Hospitalier Universitaire de Nice

ADPHUN, FRM

Investigators

Principal Investigator:

Marc Albertini, Professor

Department of Pediatrics of Nice University Hospital

More Information

Responsible Party:	CHU de Nice ( Département de la Recherche Clinique et de l'Innovation )
Study ID Numbers:	CIR 2005
Study First Received:	December 6, 2007
Last Updated:	December 6, 2007
ClinicalTrials.gov Identifier:	NCT00569361
Health Authority:	France: Direction Générale de la Santé; France: Institutional Ethical Committee

Keywords provided by Centre Hospitalier Universitaire de Nice:

allergic rhinitis to dust mite
allergic rhinitis associated with bronchial hyperreactivity
allergic rhinitis associated with asthma

Study placed in the following topic categories:

Otorhinolaryngologic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases

Asthma
Bronchial Hyperreactivity
Rhinitis

Additional relevant MeSH terms:

Nose Diseases

ClinicalTrials.gov processed this record on January 15, 2009