Androgens for Poor Responders in In Vitro Fertilization - Full Text View

Sponsored by:	Hospital Clinic of Barcelona
Information provided by:	Hospital Clinic of Barcelona
ClinicalTrials.gov Identifier:	NCT00693108

Purpose

it has been shown that androgens in non human primates may favour follicular growth in the ovaries when animals are treated with gonadotropins which are the hormones used in patients receiving treatment with in vitro fertilization. Therefore, this study investigates the potential usefulness of testosterone treatment preceding gonadotropin administration in in vitro fertilization patients having a previous poor response to gonadotropins alone.

Condition	Intervention	Phase
Ovarian Response	Drug: Transdermal testosterone	Phase III

Drug Information available for: Testosterone Methyltestosterone Oxymesterone Testosterone enanthate Testosterone Propionate Testosterone undecanoate

U.S. FDA Resources

Study Type:	Interventional
Official Title:	Transdermal Testosterone to Improve Ovarian Response to Gonadotropins in Poor Responder IVF Patients With Normal Basal Concentrations of FSH

Further study details as provided by Hospital Clinic of Barcelona:

Study Start Date:

September 2006

Arms	Assigned Interventions
1: Experimental Transdermal testosterone treatment during the five days preceding gonadotropin therapy in IVF cycles	Drug: Transdermal testosterone
2: No Intervention

Eligibility

Ages Eligible for Study:	19 Years to 39 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients receiving the second IVF treatment attempt having the first treatment cycle cancelled because of poor ovarian response to gonadotropins

Exclusion Criteria:

Previous ovarian surgery
Clinical or laboratory profile suggesting premature ovarian failure

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00693108

Locations

Spain
Hospital Clinic
Barcelona, Spain, 08036

Sponsors and Collaborators

Hospital Clinic of Barcelona

More Information

Publications:

Balasch J, Fábregues F, Peñarrubia J, Carmona F, Casamitjana R, Creus M, Manau D, Casals G, Vanrell JA. Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH. Hum Reprod. 2006 Jul;21(7):1884-93. Epub 2006 Mar 3.

Study ID Numbers:	IVFANDROGENS
Study First Received:	June 4, 2008
Last Updated:	June 5, 2008
ClinicalTrials.gov Identifier:	NCT00693108
Health Authority:	Spain: Comité Ético de Investigación Clínica

Keywords provided by Hospital Clinic of Barcelona:

Poor
Response
Ovarian

Stimulation
IVF
Patients

Study placed in the following topic categories:

Testosterone
Methyltestosterone
Testosterone 17 beta-cypionate

Additional relevant MeSH terms:

Anabolic Agents
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Therapeutic Uses
Physiological Effects of Drugs

Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones
Pharmacologic Actions
Androgens

ClinicalTrials.gov processed this record on January 16, 2009