• alcohol and drug use at baseline, six and twelve months
  
• Psychopathology at baseline, six and twelve months
  
• Global functioning at baseline, six and twelve months
  

• Quality of life at baseline, six and twelve months
  
• Therapist alliance at six and twelve months
  
• Treatment fidelity at six and twelve months
  

Patients with mental disorders and co-occuring substance use disorders are characterized by high suicide and treatment drop-out rates, and long-lasting interpersonal, work, school, health and legal problems. And because mental disorders and substance use disorders interact and co-exists, it may be important to provide treatment that integrates their substance misuse and mental health problems in a comprehensive way. The health services for patients with mental health and substance use disordes are usually provided by different services and health professionals that rarely cooperate or have qualifications on both kinds of disorders. The over-all aim of the study is to evaluate the effects of evidence-based integrated and comprehensive treatment of mental health problems and co-occurring substance use disorders. The effects of the treatment will be assesses on substance use,psychopathology, and quality of life.

Comparison: patients receiving treatment-as-usual or non-manualized treatment at general mental health outpatients clinics.