Inclusion Criteria:

• Patients must have predominantly clear cell renal cancer (75%)
• Patients must have evidence of metastatic disease. Metastatic disease should not be progressing so as to require palliative treatment (e.g., radiation, surgery, etc), within 4 weeks of enrollment.
• Patients may have received no more than two prior regimens such as immunotherapy, chemotherapy or molecular targeted agents for renal cell carcinoma with at least 1 regimen consisting of a tyrosine kinase inhibitor (sorafenib or sunitinib). Four weeks must have elapsed from previous therapy.
• Patients must have adequate physiologic reserves as evidenced by lab values
• Effective birth control must be practiced by both male and female patients

Exclusion Criteria:

• Patients with central nervous system metastases are excluded, except those patients who have had complete excision or radiotherapy and remain asymptomatic, off steroids for 21 days, with no evidence of new disease as shown by MRI
• Patients known to be HIV positive are not eligible, although testing specifically for participation in this protocol is not required.
• Patients with a recent history of TIA (within 6 months), or are requiring regular antianginal therapy or are having claudication sufficient to limit activity are not eligible. Patients with a previous history of deep venous thrombosis or pulmonary embolism are not eligible.
• Patients with active autoimmune disease.
• Patients who have had steroid therapy within the past three weeks.
• Patients involving concurrent anticancer drug therapy. Any immunosuppressive drugs or any other experimental therapy.
• Female patients who are pregnant or lactating.
• The patient has an unstable medical condition, such as uncontrolled diabetes mellitus or hypertension; active infections requiring systemic antibiotics, antivirals, or antifungals; clinical evidence of cardiac or pulmonary dysfunction including, but not limited to: unstable CHF; uncontrolled arrhythmias; unstable coagulation disorders; or recent myocardial infarction (within 6 months).
• The patient has received any investigational agent(s) within 4 weeks of study entry.
• Patients with evidence of mucosal or internal bleeding and/or platelet refractory (i.e., unable to maintain a platelet count > 50,000 cells/mm3).
• Patients unable to maintain an absolute neutrophil count (ANC) of < 1,500 cells/mm3.
• Any condition, including laboratory abnormalities, that in the opinion of the Investigator places the patient at unacceptable risk if he/she were to participate in the study.
• Prior malignancy (within the last 3 years) except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for at least 3 years.