The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation

This study is currently recruiting participants.

Verified by National Taiwan University Hospital, June 2005

Sponsored by:	National Taiwan University Hospital
Information provided by:	National Taiwan University Hospital
ClinicalTrials.gov Identifier:	NCT00173199

Purpose

In order to increase our understanding about the pathogenic mechanism and the strategy of treatment in the subtypes of Guillain Barré syndrome, we will check the temporal changes of cytokines with different biological activities in serum and cerebrospinal fluid (CSF), check the titer of various anti-ganglioside antibodies, perform skin biopsy and correlate these data with the clinical findings such as severity and prognosis

Condition
Guillain Barré Syndrome

MedlinePlus related topics: Guillain-Barre Syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study
Official Title:	The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment:	150
Study Start Date:	June 2005

Show Detailed Description

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Progressive weakness of both legs and arms; areflexia; cranial nerve involvement (such as facial palsies); progression over days to 4 wks; recovery beginning 2-4 wks after progression ceases; elevated cerebrospinal fluid protein with <10 cells/µl; electrodiagnostic features of nerve conduction slowing or block.

Exclusion criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00173199

Contacts

Contact: Sung-Tsang Hsieh, PhD

886-2-23123456 ext 8182

sthsieh@ha.mc.ntu.edu.tw

Locations

Taiwan
Department of Anatomy and Cell Biology, National Taiwan University College of Medicine	Recruiting
Taipei, Taiwan
Contact: Sung-Tsang Hsieh, PhD 886-2-23123456 ext 8182 sthsieh@ha.mc.ntu.edu.tw

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

Study Director:

Sung-Tsang Hsieh, PhD

Department of Anatomy and Cell Biology, National Taiwan University College of Medicine; Department of Neurology, National Taiwan University Hospital

More Information

Study ID Numbers:	9461700526
Study First Received:	September 12, 2005
Last Updated:	November 29, 2005
ClinicalTrials.gov Identifier:	NCT00173199
Health Authority:	Taiwan: Department of Health

Study placed in the following topic categories:

Autoimmune Diseases
Acute idiopathic polyneuritis
Guillain-Barre syndrome
Neuromuscular Diseases
Demyelinating Diseases
Polyradiculoneuropathy

Guillain-Barre Syndrome
Peripheral Nervous System Diseases
Polyneuropathies
Demyelinating diseases
Autoimmune Diseases of the Nervous System

Additional relevant MeSH terms:

Pathologic Processes
Disease
Immune System Diseases
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009