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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00173082 |
Primary aldosteronism (PA) is occasionally associated with impaired glucose tolerance. Glucose intolerance, in general metabolic syndrome is caused by suppression of insulin release from the pancreas and suppression of insulin sensitivity of the target tissues. Several studies have suggested that impaired glucose tolerance in primary aldosteronism is due to an inability of the beta cells to release insulin by potassium depletion. It was suggested glucose intolerance in PA is caused by the suppression of insulin release related to hypopotassemia and compensatory increase of insulin sensitivity is observed in PA. The increased insulin secretory capacity associated with correction of negative potassium balance may account for the increase in plasma leptin after curing primary aldosteronism. The conclusion with respect to the possible causal relationship between diabetes mellitus (DM) and PA, however, can be obtained after the evaluation of the effect of surgical /pharmacological treatment of PA.
Condition | Intervention |
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Primary Aldosteronism |
Procedure: Glucose tolerance test |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism |
Estimated Enrollment: | 100 |
Study Start Date: | June 2005 |
Estimated Study Completion Date: | July 2008 |
Primary aldosteronism (PA) is occasionally associated with impaired glucose tolerance. Glucose intolerance, in general metabolic syndrome is caused by suppression of insulin release from the pancreas and suppression of insulin sensitivity of the target tissues. Several studies have suggested that impaired glucose tolerance in primary aldosteronism is due to an inability of the beta cells to release insulin by potassium depletion. It was suggested glucose intolerance in PA is caused by the suppression of insulin release related to hypopotassemia and compensatory increase of insulin sensitivity is observed in PA. The increased insulin secretory capacity associated with correction of negative potassium balance may account for the increase in plasma leptin after curing primary aldosteronism. The conclusion with respect to the possible causal relationship between DM and PA, however, can be obtained after the evaluation of the effect of surgical /pharmacological treatment of PA. From July 2005 to July 2008, patients with primary aldosteronism, hospitalized for a comprehensive study of the subtypes of primary aldosteronism before operation will receive informed consent about the insulin sensitivity test. In the present study, we measured insulin sensitivity via the ability to release insulin by the 75 g oral glucose tolerance test (OGTT) in PA to clarify the mechanisms of glucose intolerance in PA. Seventy-five gram OGTT was performed in PA before and after adrenalectomy. Within one minute, 75 g of glucose dissolved in 200 cc water was ingested. Venous blood samples were drawn at 0, 60, 120 minutes for determination of plasma glucose and plasma insulin levels. Serum potassium levels were measures at 0 minutes. Furthermore, the adipokines, HOMA, QUICKI, leptin, adiponectin, homocystine, C-reactive protein, proinflammatory cytokine and adhesion molecules were also measured.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Vin-cent Wu, MD | +886-2-23562082 | kdw@ha.mc.ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Vincent Wu, MD +886-2-23562082 walt-wu@yahoo.com.tw |
Study Chair: | Kwan-Dun Wu, MD, PhD | National Taiwan University Hospital |
Study Director: | Vin-cent Wu, MD | National Taiwan University Hospital |
Study ID Numbers: | 9461700402 |
Study First Received: | September 12, 2005 |
Last Updated: | November 28, 2007 |
ClinicalTrials.gov Identifier: | NCT00173082 |
Health Authority: | Taiwan: Department of Health |
primary aldosteronism Insulin resistance Metabolic syndrome OGTT |
Metabolic Diseases Adrenal Gland Diseases Endocrine System Diseases Adrenocortical Hyperfunction Primary aldosteronism Insulin Hyperinsulinism |
Insulin Resistance Conn's syndrome Endocrinopathy Glucose Metabolism Disorders Metabolic disorder Hyperaldosteronism |
Pathologic Processes Disease Syndrome |