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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00172952 |
To study the clinical characteristics and inheritance of pathological myopia in Taiwanese patients.
Condition |
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Myopia |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Case Control, Retrospective/Prospective Study |
Official Title: | National Taiwan University Hospital |
Estimated Enrollment: | 600 |
Study Start Date: | June 2005 |
Estimated Study Completion Date: | January 2006 |
High myopia (pathological myopia) is caused by excessive axial elongation that primarily involves the ora-equatorial area and the posterior pole. Pathological myopia often accompanied by glaucoma, cataracts, macular degeneration, and retinal detachment, leading to blindness when the damage to the retina is extremely severe. Population and family studies in Chinese have provided evidence for a geneticcomponent to pathologic myopia. Children of myopic parents are more likely to have myopia than are children of nonmyopic parents. Therefore, it is possible to search a potential candidate gene for myopia through the genomic study of pathological myopia. The retina receives the signal from the retina-RPE complexes and affects the growth of scleral coats. The changes of scleral components, collagen fibrils and proteoglycans, are noted in experimental and human myopia and induce the pathology of high myopia. It is interesting to know that individual difference of SNP in the components of scleral coat affects the response to the signal from retina-RPE complexes. The most important effectors in scleral coats are collagens, proteoglycans, MMPs and TIMPs. Therefore, the difference of SNPs in different genes might contribute the formation of scleral thinning during myopia development. In this project, we will focus on this subject by using GenomeLab SNPstream Genotyping System which is powerful and helpful for identify some specific SNPs in the regard.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Yung-Feng Shih, MD | 886-2-23123456 ext 5184 | yfshih@ha.mc.ntu.edu.tw |
Taiwan | |
National Taiwan University Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Yung-Feng Shih, MD 886-2-23123456 ext 5184 yfshih@ha.mc.ntu.edu.tw |
Principal Investigator: | Yung-Feng Shih, MD | National Taiwan University Hospital |
Study ID Numbers: | 9461700339 |
Study First Received: | September 12, 2005 |
Last Updated: | September 12, 2005 |
ClinicalTrials.gov Identifier: | NCT00172952 |
Health Authority: | Taiwan: Department of Health |
high myopia, genomic |
Eye Diseases Myopia Refractive Errors Myopia, severe |