Long Term Outcomes of EV71 CNS Infection

This study is currently recruiting participants.

Verified by National Taiwan University Hospital, June 2005

Sponsored by:	National Taiwan University Hospital
Information provided by:	National Taiwan University Hospital
ClinicalTrials.gov Identifier:	NCT00172393

Purpose

Our study involved 142 children with EV71 CNS infections that included 61 (43%) with viral meningitis, 53 (37%) with severe CNS involvement including encephalitis, polio-like syndrome and encephalomyelitis, and 28 (20%) with cardiopulmonary failure after CNS involvement. These children were subjected to physical and neurological examinations 2.85 (range 1.0-7.39) years after disease onset. Those below the age of 6 years took the Denver developmental screening test, while those 4 years and over took the intelligence quotient (IQ) test.

Condition
Central Nervous System Infection

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study
Official Title:	Long Term Outcomes of EV71 Central Nervous System Infection

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment:	150
Study Start Date:	January 2003
Estimated Study Completion Date:	May 2005

Show Detailed Description

Eligibility

Ages Eligible for Study:	1 Month to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Virologically-confirmed EV71 cases with CNS involvement

Exclusion Criteria:

No evidence of EV71 infection
No evidence of CNS involvement

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00172393

Contacts

Contact: Luan-Yin Chang, MD

886-2-23123456 ext 3245

ly7077@tpts6.seed.net.tw

Locations

Taiwan
National Taiwan University Hsopital	Recruiting
Taipei, Taiwan, 100
Contact: Luan-Yin Chang, MD, PhD 886-2-23123456 ext 3245 ly7077@tpts6.seed.net.tw
Principal Investigator: Luan-Yin Chang, MD, PhD

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

Principal Investigator:

Luan-Yin Chang, MD, PhD

National Taiwan University Hospital

More Information

Publications indexed to this study:

Gau SS, Chang LY, Huang LM, Fan TY, Wu YY, Lin TY. Attention-deficit/hyperactivity-related symptoms among children with enterovirus 71 infection of the central nervous system. Pediatrics. 2008 Aug;122(2):e452-8. Epub 2008 Jul 7.

Chang LY, Huang LM, Gau SS, Wu YY, Hsia SH, Fan TY, Lin KL, Huang YC, Lu CY, Lin TY. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007 Mar 22;356(12):1226-34.

Study ID Numbers:	9311700446
Study First Received:	September 12, 2005
Last Updated:	October 3, 2006
ClinicalTrials.gov Identifier:	NCT00172393
Health Authority:	Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:

EV71,
CNS,
Outcome,
Neurological,
Psychiatric

Study placed in the following topic categories:

Central Nervous System Infections
Central Nervous System Diseases

Additional relevant MeSH terms:

Communicable Diseases
Nervous System Diseases
Infection

ClinicalTrials.gov processed this record on January 16, 2009