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The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

This study has been completed.

Sponsored by: China Medical University, China
Information provided by: China Medical University, China
ClinicalTrials.gov Identifier: NCT00374894
  Purpose

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.


Condition Intervention
Lead Poisoning
Drug: 2,3-dimercaptosuccinic acid

MedlinePlus related topics:   Lead Poisoning    Poisoning   

Drug Information available for:   Succimer   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Screening, Longitudinal, Defined Population, Prospective Study

Further study details as provided by China Medical University, China:

Estimated Enrollment:   500
Study Start Date:   March 2004
Estimated Study Completion Date:   August 2004

  Eligibility
Ages Eligible for Study:   3 Years to 6 Years
Genders Eligible for Study:   Both

Criteria

Inclusion Criteria:

  • Initial BLLs 100-440µg/L
  • Age 3-6y
  • No more than two main residences
  • House cleaned (no lead contaminated)
  • Normal intake history and physical

Exclusion Criteria:

  • Chelation in the past 12 weeks
  • Concomitant Fe deficiency(ferritin<16ng/ml)
  • Hemoglobin<10.5g/dL
  • Medications affecting mineral metabolism
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00374894

Locations
China, Liaoning
China Medical University    
      Shenyang, Liaoning, China, 110001

Sponsors and Collaborators
China Medical University, China

Investigators
Study Director:     Jin Ya ping, professor     Department of Environmental and Occupational Health    
  More Information


Study ID Numbers:   20032063 - 2001102049
First Received:   September 11, 2006
Last Updated:   September 11, 2006
ClinicalTrials.gov Identifier:   NCT00374894
Health Authority:   China: Ministry of Health

Keywords provided by China Medical University, China:
2,3-dimercaptosuccinic acid  
Blood Lead Levels  
children  
multi-nutrients  

Study placed in the following topic categories:
Succimer
Lead Poisoning
Poisoning
Disorders of Environmental Origin

Additional relevant MeSH terms:
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Chelating Agents
Protective Agents
Pharmacologic Actions
Antidotes

ClinicalTrials.gov processed this record on November 06, 2008




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