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DBT and Escitalopram in Borderline Personality Disorder

This study is currently recruiting participants.
Verified by Bronx VA Medical Center, November 2005

Sponsored by: Bronx VA Medical Center
Information provided by: Bronx VA Medical Center
ClinicalTrials.gov Identifier: NCT00255554
  Purpose

Subjects will receive six months of DBT, consisting of one 90-minute group and one 60-minute individual session per week as well as telephone availability of the individual therapist. Half the subjects will concurrently receive escitalopram while half will receive placebo, in a randomized double-blind design.


Condition Intervention
Borderline Personality Disorder
Behavioral: Dialectical Behavioral Therapy
Drug: Escitalopram

MedlinePlus related topics:   Personality Disorders   

Drug Information available for:   Escitalopram    Benzetimide    Citalopram    Citalopram hydrobromide    Dexetimide    Escitalopram oxalate   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment
Official Title:   Effects of Dialectical Behavioral Therapy and Escitalopram on Impulsive Aggression, Affective Instability and Cognitive Processing in Borderline Personality Disorder

Further study details as provided by Bronx VA Medical Center:

Primary Outcome Measures:
  • Measures of impulsivity, aggression, affective impulsivity, immediate and delayed memory, and cognitive processing at baseline, 6 months and 9 months

  Eligibility
Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Inclusion Criteria: Is a male or female between 18 and 60 who meets criteria for Borderline Personality Disorder and has been off psychotropic medications for at least 2 weeks (6 weeks for fluoxetine).

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Exclusion Criteria: Meets criteria for Schizophrenia, Bipolar Disorder, Mental Retardation, current or recent Substance Dependence or a current Major Depressive Episode. Subjects also should not currently be in individual psychotherapy. (Case management and work therapy programs are allowed.)

-

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00255554

Contacts
Contact: Emily Hart     212-241-0441     mpgroup@mssm.edu    

Locations
United States, New York
Bronx VA Medical Center     Recruiting
      Bronx, New York, United States, 10029

Sponsors and Collaborators
Bronx VA Medical Center

Investigators
Principal Investigator:     Marianne Goodman, MD     Bronx VA Medical Center/Mount Sinai School of Medicine    
  More Information


Study ID Numbers:   3277-03-0027
First Received:   November 17, 2005
Last Updated:   November 17, 2005
ClinicalTrials.gov Identifier:   NCT00255554
Health Authority:   United States: Federal Government

Keywords provided by Bronx VA Medical Center:
Borderline Personality Disorder  
BPD  
Dialectical Behavior Therapy  
DBT
Escitalopram
Lexapro

Study placed in the following topic categories:
Mental Disorders
Dexetimide
Aggression
Borderline Personality Disorder
Citalopram
Serotonin
Personality Disorders

Additional relevant MeSH terms:
Parasympatholytics
Neurotransmitter Uptake Inhibitors
Neurotransmitter Agents
Disease
Molecular Mechanisms of Pharmacological Action
Cholinergic Antagonists
Anti-Dyskinesia Agents
Physiological Effects of Drugs
Psychotropic Drugs
Antiparkinson Agents
Cholinergic Agents
Serotonin Uptake Inhibitors
Pharmacologic Actions
Muscarinic Antagonists
Serotonin Agents
Pathologic Processes
Autonomic Agents
Therapeutic Uses
Peripheral Nervous System Agents
Antidepressive Agents, Second-Generation
Central Nervous System Agents
Antidepressive Agents

ClinicalTrials.gov processed this record on November 06, 2008




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