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Prepulse Inhibition of Startle in Cocaine Dependence - 7

This study has been completed.

Sponsors and Collaborators: National Institute on Drug Abuse (NIDA)
New York MDRU
Information provided by: National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier: NCT00015249
  Purpose

The purpose of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.


Condition Intervention Phase
Cocaine-Related Disorders
Substance-Related Disorders
Drug: Amantadine
Phase I

Drug Information available for:   Amantadine    Amantadine hydrochloride    Amantadine sulfate    8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-    Cocaine hydrochloride   

U.S. FDA Resources

Study Type:   Interventional
Study Design:   Diagnostic, Double-Blind, Placebo Control
Official Title:   Prepulse Inhibition of Startle in Cocaine Dependence (Human)

Further study details as provided by National Institute on Drug Abuse (NIDA):

Primary Outcome Measures:
  • Percent prepulse inhibition
  • Cocaine assessment

Estimated Enrollment:   0
Study Start Date:   February 1997

Detailed Description:

The objective of this study is to assess the effects of chronic cocaine use on the acoustic startle response and on gating of this response in humans.

  Eligibility
Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Criteria

Inclusion Criteria:

Cocaine dependence. Male. Right handed. Negative urine for cocaine

Exclusion Criteria:

Positive urine for cocaine. History of head trauma. Significant medical disease.

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00015249

Locations
United States, New York
New York MDRU    
      New York, New York, United States, 10010

Sponsors and Collaborators

Investigators
Principal Investigator:     John Rotrosen, M.D.     New York MDRU    
  More Information


Study ID Numbers:   NIDA-5-0013-7, Y01-5-0013-7
First Received:   April 18, 2001
Last Updated:   November 3, 2005
ClinicalTrials.gov Identifier:   NCT00015249
Health Authority:   United States: Federal Government

Study placed in the following topic categories:
Cocaine-Related Disorders
Dopamine
Mental Disorders
Substance-Related Disorders
Disorders of Environmental Origin
Cocaine
Amantadine

Additional relevant MeSH terms:
Anti-Infective Agents
Neurotransmitter Agents
Disease
Molecular Mechanisms of Pharmacological Action
Anti-Dyskinesia Agents
Physiological Effects of Drugs
Antiparkinson Agents
Antiviral Agents
Pharmacologic Actions
Pathologic Processes
Sensory System Agents
Analgesics, Non-Narcotic
Therapeutic Uses
Dopamine Agents
Peripheral Nervous System Agents
Analgesics
Central Nervous System Agents

ClinicalTrials.gov processed this record on November 05, 2008




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