The Department of Energy is an integral part of the United States’ efforts to reduce global danger from weapons of mass destruction.  The Deputy Administrator for Defense Nuclear Nonproliferation within Energy's National Nuclear Security Administration (NNSA) is responsible for the enhancement of United States national security through the following four-part strategy:

• Protecting or eliminating weapons and weapons-useable nuclear material or infrastructure, and redirecting excess foreign weapons expertise to civilian enterprises;
• Preventing and reversing the proliferation of weapons of mass destruction;
• Reducing the risk of accidents in nuclear fuel cycle facilities worldwide; and
• Enhancing the capability to detect weapons of mass destruction, including nuclear, chemical and biological systems.