• The incidence of complete ulcer closure [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
  

Inclusion Criteria:

• Ages 20 or older with diabetes mellitus (Type 1 or 2) who has a cutaneous ulcer on the foot and present for at least 4 weeks
• The target ulcer is classified as a grade 1 ulcer according to Wagner system and is ranging in size between 3 and 15 cm2 post debridement.
• An ankle brachial index ≥0.80.
• The study ulcer should show "infection control" as judged by the investigator
• The subject should be free of any necrotic or infected soft and bony tissue.
• Signed informed consent form.

Exclusion Criteria:

• Ulcers caused by venous or arterial insufficiency, osteomyelitis.
• Poor nutritional status (albumin < 3g/dl), poor diabetic control (HbA1c > 10%), anemia (hemoglobin<10 g/dL), a leukocyte counts < 1,000/cumm.
• Requiring prostaglandin treatment.
• Requiring treatment with corticosteroids, immunosuppressive or chemotherapeutic agents, radiotherapy.
• Presence of necrosis, purulence or sinus tracts that cannot be removed by debridement.
• resence of connective tissue disease, renal failure (serum creatinine > 1.5 mg/dl), abnormal liver function (AST, ALT>2.5x upper limit of normal range), malignancy.
• vascularization surgery performed <8 weeks before entry in the study.
• Proliferative retinopathy, pre-proliferative retinopathy.
• A history of cerebravascular events, coronary intervention (stent or coronary artery bypass graft (CABG)) or myocardial infarction, within 6 months prior to study.
• Female patient who has a positive pregnancy test or who is breastfeeding or unwilling to use appropriate contraceptive methods during study.