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Sponsored by: |
Vanderbilt University |
Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00608348 |
The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity.
Condition | Intervention |
Diabetes Mellitus |
Procedure: Hyperinsulinemic glucose clamp procedures Procedure: moderate exercise |
MedlinePlus related topics: | Diabetes Exercise and Physical Fitness Hypoglycemia |
Drug Information available for: | Dextrose |
Study Type: | Interventional |
Study Design: | Other, Randomized, Open Label, Active Control, Factorial Assignment |
Official Title: | Sympathetic Nerve Activity During Hypoglycemia and Exercise |
Estimated Enrollment: | 36 |
Study Start Date: | April 2002 |
Study Completion Date: | July 2008 |
Primary Completion Date: | July 2008 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
1: Experimental
Hyperinsulinemic euglycemic or hypoglycemic clamp with Muscle and skin sympathetic nerve activity recording in arm and/or leg
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Procedure: Hyperinsulinemic glucose clamp procedures
2 hours of either euglycemic or hypoglycemic glucose clamping
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2: Experimental
Exercise with insulin or no insulin infused with muscle and skin sympathetic nerve activity measurements
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Procedure: moderate exercise
90 minutes of moderate exercise with either hyperinsulinemia or euinsulinemia
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The body has defensive responses to correct low blood sugar (hypoglycemia). A vital component of this response is release of glucagon and activation of the sympathetic nervous system, which provides the means for raising blood glucose levels towards normal. We can measure circulating hormones indicating the level of these responses, but additionally, sympathetic nervous system responses can be measured directly. We can measure the sympathetic nerve activity that controls blood flow to muscles (MSNA) and blood flow and sweating to skin (SSNA). The purpose of this study is to determine if either hypoglycemia or exercise cause differential responses in muscle and skin sympathetic nerve activity. We would also like to determine what the sympathetic response is to cycling exercise with insulin and normal blood sugar. Therefore, we would like to test the sympathetic responses to insulin with normal blood glucose, hypoglycemia, and during exercise bouts and normal blood glucose, with or without insulin.
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
United States, Tennessee | |||||
Vanderbilt University | |||||
Nashville, Tennessee, United States, 37232 |
Vanderbilt University |
Principal Investigator: | Stephen N. Davis, MD | Vanderbilt University |
Responsible Party: | Vanderbilt University ( Stephen N. Davis, MD ) |
Study ID Numbers: | IRB#020777-SNA during hypo/ex |
First Received: | January 29, 2008 |
Last Updated: | August 5, 2008 |
ClinicalTrials.gov Identifier: | NCT00608348 |
Health Authority: | United States: Institutional Review Board |
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