• Dose-limiting toxicity [ Time Frame: for the duration of the trial ] [ Designated as safety issue: Yes ]
  
• Maximum tolerated dose [ Time Frame: for the duration of the trial ] [ Designated as safety issue: Yes ]
  

• Toxicity [ Time Frame: for the duration of the trial ] [ Designated as safety issue: Yes ]
  
• Pharmacokinetics [ Time Frame: for the duration of the trial ] [ Designated as safety issue: No ]
  
• Antitumor activity [ Time Frame: for the duration of the trial ] [ Designated as safety issue: No ]
  

Drug: HuC242-DM4
Dose escalation study to define maximum tolerated dose. Doses will vary per cohort. Patients will receive an IV infusion once every three weeks.

OBJECTIVES:

Primary

• Determine the dose-limiting toxicity and maximum tolerated dose of maytansinoid DM4-conjugated humanized monoclonal antibody huC242 in patients with inoperable or metastatic colorectal cancer, pancreatic cancer, or other solid tumors.

Secondary

• Determine the qualitative and quantitative toxicities of this drug in these patients.
• Characterize the pharmacokinetics of this drug in these patients.
• Describe any antitumor activity of this drug in these patients.

OUTLINE: This is an open-label, nonrandomized, dose-escalation study.

Patients receive maytansinoid DM4-conjugated humanized monoclonal antibody huC242 IV over 4-5 hours on day 1. Treatment repeats every 3 weeks in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of maytansinoid DM4-conjugated humanized monoclonal antibody huC242 until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients experience dose-limiting toxicity. Up to 15 patients are treated at the MTD.

Patients undergo blood collection at baseline and periodically during study for pharmacokinetic studies.

After completion of study treatment, patients are followed at 30 days.

PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

• Histologically confirmed solid tumor

  • Inoperable or metastatic disease
• Failed standard therapy

• Confirmed cancer antigen (CanAg) expression

  • Patients with colorectal cancer or pancreatic cancer may be enrolled prior to confirmation of CanAg expression
  • Tumor must have a homogeneous pattern (i.e., staining present in > 75% of tumor cells for CanAg) and are 2+ or 3+ intensity by immunohistochemistry (for patients enrolled after the maximum tolerated dose of study drug has been determined)
• No known leptomeningeal disease or progressive brain disease

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2
• Life expectancy ≥ 12 weeks
• Absolute neutrophil count ≥ 1,500/mm³
• Hemoglobin ≥ 9 g/dL (transfusion allowed)
• Platelet count ≥ 100,000/mm³
• aPTT and INR ≤ 1.5 times upper limit of normal (ULN)
• Creatinine ≤ 1.5 mg/dL
• Creatinine clearance ≥ 60 mL/min
• Bilirubin ≤ 1.5 mg/dL
• AST and ALT < 2.5 times ULN
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 30 days after completion of study treatment
• No hypersensitivity to agents of the same class as the study drug, humanized or nonhumanized antibodies, or immunoconjugates
• No active, uncontrolled infection
• No hepatitis B surface antigen or hepatitis C antibody positivity
• No history of alcoholic liver disease
• No serious medical or psychiatric disorder that would preclude compliance with study requirements
• No peripheral neuropathy > grade 1
• No other malignancy within the past 2 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or stage A low-grade prostate cancer
• No severe concurrent disease or condition that, in the opinion of the investigator, would preclude study participation

PRIOR CONCURRENT THERAPY:

• Recovered from prior therapy
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas and mitomycin C)
• At least 4 weeks since prior radiotherapy, immunotherapy, or hormone therapy for cancer
• At least 4 weeks since prior major surgery

• No concurrent chemotherapy, other immunotherapy, radiotherapy, or other investigational therapy

  • Palliative radiotherapy for related bone metastases allowed
• No other concurrent anticancer therapy
• Concurrent bisphosphonates allowed provided it was started before initiation of study therapy and patient is maintained on a stable dose