DNA evidence can become contaminated when DNA from another source gets mixed with DNA relevant to the case. For this reason, investigators and laboratory personnel should always wear disposable gloves, use clean instruments, and avoid touching other objects, including their own body, when handling evidence.
Environmental factors, such as heat and humidity, can also accelerate the degradation of DNA. For example, wet or moist evidence that is packaged in plastic will provide a growth environment for bacteria that can destroy DNA evidence.