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| Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00018889 |
Purpose
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.
| Condition |
|
Movement Disorder |
| Genetics Home Reference related topics: | essential tremor familial paroxysmal nonkinesigenic dyskinesia Friedreich ataxia |
| MedlinePlus related topics: | Movement Disorders |
| Study Type: | Observational |
| Official Title: | Phenotype/Genotype Correlations in Movement Disorders |
| Estimated Enrollment: | 500 |
| Study Start Date: | July 2001 |
The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype/genotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.
Eligibility
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Individuals with known or suspected inherited movement disorders.
Families where multiple family members that are affected with a movement disorder.
EXCLUSION CRITERIA:
Pregnant women will be excluded from any tests involving radiation treatment.
Contacts and Locations| Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
| Contact: TTY | 1-866-411-1010 |
| United States, Maryland | |||||
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting | ||||
| Bethesda, Maryland, United States, 20892 | |||||
More Information
NIH Clinical Center Detailed Web Page
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| Study ID Numbers: | 010206, 01-N-0206 |
| First Received: | July 7, 2001 |
| Last Updated: | July 18, 2008 |
| ClinicalTrials.gov Identifier: | NCT00018889 |
| Health Authority: | United States: Federal Government |
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