Effect of Antidepressants on Back Pain - Full Text View

Purpose

The purpose of this study is to determine whether different types of antidepressant medicines relieve back pain that has lasted at least six months on a daily basis. Study participants will be assigned to treatment with either a antidepressant acting on the serotonin system in the brain (fluoxetine), one acting on the noradrenoline system (desipramine, or to a control medication not expected to relieve pain (benztropine). Each participant will be seen at least nine times during their 12 weeks on medication. This is a phase 2/3, outpatient study.

Condition	Intervention	Phase
Back Pain Sciatica	Drug: Fluoxetine Drug: Desipramine Drug: Benztropine	Phase II

MedlinePlus related topics:

Antidepressants Back Pain Sciatica

Drug Information available for:

Benztropine Benzatropine methanesulfonate Desipramine Desipramine hydrochloride Fluoxetine Fluoxetine hydrochloride

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study

Official Title:	Efficacy of Antidepressants in Chronic Back Pain

Further study details as provided by Department of Veterans Affairs:

Study Start Date:	April 1999
Estimated Study Completion Date:	March 2002

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Chronic back pain (pain on a daily basis for six months or longer)
Age 18-65
No major medical illness

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00018200

Locations


United States, California
	Department of Veterans Affairs
	San Diego, California, United States, 92161

Sponsors and Collaborators

Department of Veterans Affairs

Investigators


Investigator:	Mark A Slater, Ph.D

Investigator:	Edmund V Capparelli, Pharm.D.

Investigator:	Mark Wallace, M.D.

Investigator:	Steve R Garfin, M.D.

More Information

Study ID Numbers:	ADRD-018-98F
First Received:	July 3, 2001
Last Updated:	June 23, 2005
ClinicalTrials.gov Identifier:	NCT00018200
Health Authority:	United States: Federal Government

Keywords provided by Department of Veterans Affairs:

Back pain

sciatica

analgesia

Study placed in the following topic categories:

Neuralgia

Pain

Desipramine

Back Pain

Mononeuropathies

Serotonin

Sciatica

Fluoxetine

Signs and Symptoms

Dopamine

Neuromuscular Diseases

Peripheral Nervous System Diseases

Neurologic Manifestations

Benztropine

Additional relevant MeSH terms:

Sciatic Neuropathy

Dopamine Uptake Inhibitors

Parasympatholytics

Neurotransmitter Agents

Neurotransmitter Uptake Inhibitors

Cholinergic Antagonists

Molecular Mechanisms of Pharmacological Action

Adrenergic Agents

Anti-Dyskinesia Agents

Adrenergic Uptake Inhibitors

Physiological Effects of Drugs

Psychotropic Drugs

Antiparkinson Agents

Cholinergic Agents

Therapeutic Uses

Antidepressive Agents, Second-Generation

Antidepressive Agents

Nervous System Diseases

Enzyme Inhibitors

Serotonin Uptake Inhibitors

Pharmacologic Actions

Antidepressive Agents, Tricyclic

Muscarinic Antagonists

Serotonin Agents

Autonomic Agents

Dopamine Agents

Peripheral Nervous System Agents

Central Nervous System Agents

ClinicalTrials.gov processed this record on October 31, 2008

Sponsored by:	Department of Veterans Affairs
Information provided by:	Department of Veterans Affairs
ClinicalTrials.gov Identifier:	NCT00018200