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Sponsored by: |
Memorial Sloan-Kettering Cancer Center |
Information provided by: | Memorial Sloan-Kettering Cancer Center |
ClinicalTrials.gov Identifier: | NCT00582322 |
The purpose of this study is to determine the specific genetic alterations associated with breast cancer. This will leat to a better understanding of the genetic causes of breast cancer.
Condition |
Breast Cancer Ovarian Cancer |
Genetics Home Reference related topics: | breast cancer |
MedlinePlus related topics: | Breast Cancer Cancer Ovarian Cancer |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Genetic Studies in Breast Cancer |
blood
Enrollment: | 483 |
Study Start Date: | February 1992 |
Estimated Study Completion Date: | December 2008 |
Estimated Primary Completion Date: | December 2008 (Final data collection date for primary outcome measure) |
It is estimated that 175,000 new breast cancer cases and 44,5000 cancer deaths will result from female breast cancer in 1991. One of the most important risk factors is a family history of breast cancer. A susceptibility allele which accounts for a large proportion of familial breast cancer has been localized to chromosome 17q and attempts to clone the susceptibility are proceeding rapidly. The existence of recognized susceptibility loci and the awareness of a significan proportion of genetic predisposition and the associated penetrances remain unknown and are impossible to estimate without bias from previous studies. This study is designed to estimate heterogeniety and prenetrance in a series of unslected families, identify additional breast cancer susceptibility locs, as well as provide resources for gene isolation and mutation analysis studies.
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Patients with breast cancer seen at MSKCC and healthy family members.
Inclusion Criteria:
Exclusion Criteria:
N/A
United States, New York | |||||
Memorial Sloan-Kettering Cancer Center | |||||
New York, New York, United States, 10065 |
Memorial Sloan-Kettering Cancer Center |
Principal Investigator: | Teresa Gilewski, MD | Memorial Sloan-Kettering Cancer Center |
Memorial Sloan-Kettering Cancer Center 
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Responsible Party: | Memorial Sloan-Kettering Cancer Center ( Teresa Gilewski, MD ) |
Study ID Numbers: | 92-007 |
First Received: | December 21, 2007 |
Last Updated: | April 17, 2008 |
ClinicalTrials.gov Identifier: | NCT00582322 |
Health Authority: | United States: Food and Drug Administration |
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