Magnetic Resonance Imaging of Brain Development in Autism - Full Text View

Magnetic Resonance Imaging of Brain Development in Autism

This study is currently recruiting participants.
Verified by UMC Utrecht, March 2007

Sponsored by:	UMC Utrecht
Information provided by:	UMC Utrecht
ClinicalTrials.gov Identifier:	NCT00449566

Purpose

The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.

Condition

Autism

MedlinePlus related topics:

Autism MRI Scans

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Case Control, Prospective Study

Official Title:	Magnetic Resonance Imaging of Brain Development in Autism

Further study details as provided by UMC Utrecht:

Estimated Enrollment:	300
Study Start Date:	January 2006

Eligibility

Ages Eligible for Study:	6 Years to 18 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Aged 6 - 18 years at initial MRI

Inclusion criteria for subjects with autism

1) DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview

Inclusion criteria for controls

no DSM-IV (APA, 1994) diagnosis, according to DISC interview
no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
IQ > 70

Exclusion Criteria:

major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
presence of metal objects in or around the body (pacemaker, dental braces)
history of or present neurological disorder
for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00449566

Contacts


Contact: Sarah Durston	+31 30 250 8161	S.Durston@umcutrecht.nl

Locations


Netherlands
	Dept. of Child and Adolescent Psychiatry, UMC Utrecht	Recruiting
	Utrecht, Netherlands, 3584CX
	Contact: Marieke Langen, M.Sc. +31 30 250 7084 M.Langen@umcutrecht.nl
	Principal Investigator: Marieke Langen, M.Sc.
	Principal Investigator: Hilde Nederveen, M.Sc.

Sponsors and Collaborators

UMC Utrecht

Investigators


Principal Investigator:	Sarah Durston, Ph.D.	Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht

Study Chair:	Herman van Engeland, M.D. Ph.D.	Rudolf Magnust Institute of Neuroscience, UMC Utrecht

More Information

Lab homepage with info for subjects (in Dutch) This link exits the ClinicalTrials.gov site

Lab homepage with info in English This link exits the ClinicalTrials.gov site

Publications:

Langen M, Durston S, Staal WG, Palmen SJ, van Engeland H. Caudate Nucleus Is Enlarged in High-Functioning Medication-Naive Subjects with Autism. Biol Psychiatry. 2007 Jan 12; [Epub ahead of print]

Study ID Numbers:	METC 05/208-K
First Received:	March 18, 2007
Last Updated:	March 18, 2007
ClinicalTrials.gov Identifier:	NCT00449566
Health Authority:	Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by UMC Utrecht:

Magnetic Resonance Imaging

Diffusion Tensor Imaging

Study placed in the following topic categories:

Child Development Disorders, Pervasive

Developmental Disabilities

Mental Disorders

Autistic Disorder

Mental Disorders Diagnosed in Childhood

ClinicalTrials.gov processed this record on October 31, 2008