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Sponsors and Collaborators: |
Assistance Publique - Hôpitaux de Paris Institut de l'Atherothrombose |
Information provided by: | Assistance Publique - Hôpitaux de Paris |
ClinicalTrials.gov Identifier: | NCT00445835 |
Coronary artery disease is the first cause of death related to atherothrombosis. There is a close correlation between the extension of coronary artery disease and the severity of atherosclerotic lesions in extra coronary arterial beds. In addition, these symptomatic extracoronary lesions dramatically decrease the survival of these patients. However, scant data are available regarding the prevalence of extracoronary asymptomatic lesions. Conversely, the annual absolute risk of these lesions remains unknown. Consequently, whether a systematic identification of these extracoronary asymptomatic lesions is relevant remains to be established. The Primary Objective and Primary Endpoint of the AMERICA study is to demonstrate the superiority of an active detection and management of the extension of atherothrombosis in high Risk coronary patients (active strategy) in comparison with standard of care for coronary atherosclerosis (conservative strategy).
Condition | Intervention |
Coronary Artery Disease |
Behavioral: arterial doppler for screening asymptomatic and significant extracoronary arterial stenoses in all arterial beds |
MedlinePlus related topics: | Coronary Artery Disease |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Active Detection and Management of the Extension of Atherothrombosis in High Risk Coronary Patients In Comparison With Standard of Care for Coronary Atherosclerosis: The AMERICA Study |
Estimated Enrollment: | 526 |
Study Start Date: | April 2007 |
Estimated Study Completion Date: | May 2010 |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion criteria:
Contact: Jean-Philippe COLLET, MD PhD | +33 1 42 16 29 62 ext +33 1 42 16 29 | jean-philippe.collet@psl.aphp.fr |
Show 19 Study Locations |
Assistance Publique - Hôpitaux de Paris |
Institut de l'Atherothrombose |
Principal Investigator: | Jean-Philippe COLLET, MD PhD | Assistance Publique - Hôpitaux de Paris |
Study ID Numbers: | P060902, PHAO 2006 |
First Received: | March 8, 2007 |
Last Updated: | March 14, 2007 |
ClinicalTrials.gov Identifier: | NCT00445835 |
Health Authority: | France: Ministry of Health |
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