Survey in Patients With Chronic Adrenal Insufficiency in Germany - Full Text View

Purpose

The purpose of this survey is to assess patients with chronic primary or secondary adrenal failure regarding subjective health status, incidence and causes of adrenal crisis, hormone replacement regimens and concomitant endocrine or non endocrine disease.

Condition

Adrenal Insufficiency
Addison's Disease

Genetics Home Reference related topics:

beta-ketothiolase deficiency familial encephalopathy with neuroserpin inclusion bodies L1 syndrome leukoencephalopathy with vanishing white matter X-linked adrenoleukodystrophy

MedlinePlus related topics:

Addison's Disease

Drug Information available for:

Epinephrine Epinephrine bitartrate

U.S. FDA Resources

Study Type:	Observational
Study Design:	Psychosocial, Cross-Sectional, Defined Population, Retrospective/Prospective Study

Further study details as provided by University of Wuerzburg:

Study Start Date:	May 2004
Estimated Study Completion Date:	April 2005

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

age > 18 years
chronic adrenal failure with disease duration > 12 months and hormone replacement therapy for cortisol deficiency

Exclusion Criteria:

adrenal insufficiency due to adrenocortical carcinoma
AI due to long-term pharmacological glucocorticoid treatment
glucocortiocid doses above 7.5 mg prednisolone equivalent for other reasons than AI

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00444119

Locations


Germany
	University of Wuerzburg, Dept of Medicine - Endocrine and Diabetes unit
	Wuerzburg, Germany, D-97080
	Dept of Medicine, Gastroenterology, Hepatology and Endocrinology, Charité Campus Mitte, Charité, University Medicine Berlin
	Berlin, Germany, D-10117

Sponsors and Collaborators

University of Wuerzburg

Investigators


Principal Investigator:	Bruno Allolio, MD	University of Wuerzburg

More Information

Publications indexed to this study:

Hahner S, Loeffler M, Fassnacht M, Weismann D, Koschker AC, Quinkler M, Decker O, Arlt W, Allolio B. Impaired subjective health status in 256 patients with adrenal insufficiency on standard therapy based on cross-sectional analysis. J Clin Endocrinol Metab. 2007 Oct;92(10):3912-22. Epub 2007 Aug 7.

Study ID Numbers:	Wü_NNRIS_45/04
First Received:	March 5, 2007
Last Updated:	March 5, 2007
ClinicalTrials.gov Identifier:	NCT00444119
Health Authority:	Germany: Ethics Commission

Keywords provided by University of Wuerzburg:

adrenal insufficiency

subjective health status

quality of life

adrenal crisis

hormone replacement

DHEA

Study placed in the following topic categories:

Addison's disease

Adrenal Gland Diseases

Quality of Life

Demyelinating diseases

Brain Diseases

Hypoadrenalism

Metabolism, Inborn Errors

Heredodegenerative Disorders, Nervous System

Peroxisomal Disorders

Adrenoleukodystrophy

Addison Disease

Genetic Diseases, X-Linked

Brain Diseases, Metabolic, Inborn

Epinephrine

Neurobehavioral Manifestations

X-linked adrenoleukodystrophy

Adrenal Insufficiency

Autoimmune Diseases

Metabolic Diseases

Demyelinating Diseases

Central Nervous System Diseases

Endocrine System Diseases

Adrenal gland hypofunction

Mental Retardation

Genetic Diseases, Inborn

Neurologic Manifestations

Endocrinopathy

Metabolic disorder

Brain Diseases, Metabolic

Additional relevant MeSH terms:

Immune System Diseases

Nervous System Diseases

Mental Retardation, X-Linked

Hereditary Central Nervous System Demyelinating Diseases

ClinicalTrials.gov processed this record on October 31, 2008

Sponsored by:	University of Wuerzburg
Information provided by:	University of Wuerzburg
ClinicalTrials.gov Identifier:	NCT00444119