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| Sponsored by: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| Information provided by: | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| ClinicalTrials.gov Identifier: | NCT00000406 |
Purpose
To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.
| Condition | Intervention | Phase |
|
Osteoarthritis, Knee |
Procedure: Progressive resistance exercise |
Phase II |
| MedlinePlus related topics: | Exercise and Physical Fitness Osteoarthritis |
| Study Type: | Interventional |
| Study Design: | Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study |
| Official Title: | Effects of Strength Training on Knee Osteoarthritis (OA) |
| Estimated Enrollment: | 280 |
| Study Start Date: | September 1977 |
| Study Completion Date: | November 2006 |
| Primary Completion Date: | November 2006 (Final data collection date for primary outcome measure) |
Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain.
In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.
Eligibility
| Ages Eligible for Study: | 60 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, Indiana | |||||
| National Institute for Fitness and Sport | |||||
| Indianapolis, Indiana, United States, 46202 | |||||
| Principal Investigator: | Alan Mikesky, PhD | Indiana University School of Medicine |
More Information
| Study ID Numbers: | P60 AR20582 Substudy EEHSR3, NIAMS-022 |
| First Received: | November 3, 1999 |
| Last Updated: | December 20, 2007 |
| ClinicalTrials.gov Identifier: | NCT00000406 |
| Health Authority: | United States: Federal Government |
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