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Sponsored by: |
Emory University |
Information provided by: | Emory University |
ClinicalTrials.gov Identifier: | NCT00385151 |
Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis. A phenomenon known as Pre-conditioning has been identified to limit the the extent and severity of reperfusion injury but it is very difficult to apply it in patient care setting as timing of acute cardiac or neurologic ischemic event is difficult to reliably predict.
Postconditioning or ischemic postconditioning is well known to attenuate the reperfusion injury. There is enough data that shows the benefit of post conditioning in reducing the reperfusion injury in animals. However postconditioning in humans has not been investigated.
We hypothesize that Post conditioning will attenuate the reperfusion injury and will be comparable to the effect of preconditioning in humans.
Condition |
Endothelial Dysfunction |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Case Control, Prospective Study |
Official Title: | The Mechanism of Ischemic Post Conditioning in Humans, Minimizing Reperfusion Injury. |
Estimated Enrollment: | 20 |
Study Start Date: | May 2006 |
Estimated Study Completion Date: | August 2006 |
Show Detailed Description |
Ages Eligible for Study: | 15 Years to 35 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Don't have the following risk factor
Exclusion Criteria:
Patients with significant medial illness for which they are receiving continued monitoring or treatment, known cardiovascular disease, or risk factors for coronary artery disease are excluded. These risk factors include
The exclusion criteria are to prevent the confounding effects of atherosclerosis or other medical conditions in our study.
United States, Georgia | |||||
Emory University Hospital | |||||
Atlanta, Georgia, United States, 30322 | |||||
Emory University Hospital | |||||
Atlanta, Georgia, United States, 30322 |
Emory University |
Principal Investigator: | Tarek Helmy, MD | Emory University |
Principal Investigator: | Arshed Ali Quyyumi, MD | Emory University |
Study Director: | Muhammad Amer, MD | Emory University |
Study ID Numbers: | IRB-920-2004 |
First Received: | October 3, 2006 |
Last Updated: | October 3, 2006 |
ClinicalTrials.gov Identifier: | NCT00385151 |
Health Authority: | United States: Institutional Review Board |
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